The synthetic method of 1-(4-fluorophenyl)-2-methyl-2-propylamine

Abstract

The invention relates to the synthesis of organic substances, in particular to a synthetic method of 1-(4-fluorophenyl)-2-methyl-2-propylamine, comprising the following steps of: firstly, synthesizing 1,1-dimethyl parafluorobenzoic alcohol: adding magnesium powder dried at 95 DEG C by heating into an organic solution of parafluorobenzoic chloride to react, then dropping acetone to react, and then adding 5-20 percent of diluted hydrochloric acid solution, depositing a lemon-yellow organic phase and distilling off the organic solution by a rotary atmometer; secondly, synthesizing parafluoro acylamide: adding acetonitrile and acid liquor which are used as raw materials into the 1,1-dimethyl parafluorobenzoic alcohol to react, then distilling off the acetonitrile, adding a reaction liquid into water, then adding sodium hydroxide for neutralizing until the pH value reaches 6-7, separating out white solid particles, filtering and washing; and thirdly, synthesizing the 1-(4-fluorophenyl)-2-methyl-2-propylamine: adding the parafluoro acylamide and potassium hydroxide solution into a high pressure kettle, replacing with nitrogen, and then depositing a lemon-yellow oil layer to obtain a crude product. The invention has reasonable synthesis route, mild reaction, easy operation, low cost of raw materials, high product yield and high purity.

Description

1. Technical field: [0001] The present invention relates to the synthetic method of compound. 2. Background technology: [0002] 1-(4-fluorophenyl)-2-methyl-2-propanamine, molecular formula C 10 h 14 FN, molecular weight 167.22, English name: 1-(4-Fluorophenyl)-2-methyl-2-propylamine, the current synthetic method is to synthesize p-fluoroamide as raw material, the raw material cost is high, and the process conditions are harsh, and the product yield Low purity and low purity limit its application fields. 3. Contents of the invention: [0003] The object of the present invention is to overcome above-mentioned insufficient problem, provide a kind of synthetic method of 1-(4-fluorophenyl)-2-methyl-2-propanamine, reaction route is simple and reasonable, reaction temperature is close, easy to operate, product yield high. [0004] The technical solution adopted by the present invention for achieving the above object is: a kind of synthetic method of 1-(4-fluorophenyl)-2-meth...

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Problems solved by technology

[0002] 1-(4-fluorophenyl)-2-methyl-2-propanamine, molecular formula C 10 h 14 FN, molecular weight 167.22, English name: 1-(4-Fluorophenyl)-2-methyl-2-propylamine, the current synthetic method is to synthesize p-fluoroamide as raw material, the raw material cost is high, and the process conditions are harsh, and the product yield Low, low purity, which limits its application field

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