Medicine application of iron liposome

Abstract

The invention discloses a medicine application of iron liposome. By taking animals with chronic inflammation as a model, a brand-new medicine which treats anaemia caused by the dysfunction of the iron absorption of the small intestine to relevant protein molecules and takes the iron liposome as an effective component is provided. The invention takes white rats with inflammatory anaemia as a model, adopts an oral stomach infusion method and compares the curative effect of the iron liposome for the anaemia with that of a chalybeate which is not enveloped by the liposome, and the iron liposome can obviously enhance the levels of the hemoglobin, the blood cell volume, the serum iron and the saturation rate of the transferrin of an organism in a short time, can act as a very good curative effect to the inflammatory anaemia and can not cause injuries to the health of the organism. The iron liposome is obviously superior to the traditional iron-replenished preparation. The invention can be used for treating the anaemia caused by the dysfunction of the iron absorption of the small intestine to the protein molecules because of various known or unknown reasons. Various tablets, capsules, dripping pills, oral liquid and food additives which are taken orally and contain the iron liposome are prepared.

Description

technical field [0001] The invention relates to the pharmaceutical application of the iron liposome, in particular to its application in the preparation of medicines for treating anemia. Background technique [0002] The absorption of iron by the body mainly includes the absorption of inorganic iron and heme iron in food by small intestinal absorptive cells. got a preliminary understanding. The absorption mechanism of inorganic iron in the small intestine is as follows: iron in the food is first reduced to divalent iron by duodenal cytochrome b (duodenal cytochrome b, Dcytb), and the divalent metal ion transporter (divalent metal transporter, DMT1) Under the action, the absorption cells of the small intestinal mucosa take iron into the cells, a part of the iron can be combined with ferritin (ferritin) and stored in the cells, and a part of the iron can be transported out under the transport of ferroportin 1 (FPN1). Small intestinal cells are oxidized to trivalent under the...

AI Technical Summary

Problems solved by technology

Anemia of chronic disease has become a difficult problem in modern medical treatment. At present, the commonly used treatment methods include blood transfusion, EPO treatment and taking iron supplements. The first two methods have great application limitations and risks, while the absorption rate of conventional iron supplements Very low, it is impossible to achieve the desired therapeutic effect

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