Medicine application of iron liposome

A technology of plastids and iron lipids, which is applied in the application field of preparing medicines for treating anemia, can solve the problems of inability to achieve ideal therapeutic effects, low absorption rate, etc. Effect

Inactive Publication Date: 2010-05-19
HEBEI NORMAL UNIV
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Problems solved by technology

Anemia of chronic disease has become a difficult problem in modern medical treatment. At present, the commonly used treatment methods include blood transfusion, EPO treatment and taking iron supplemen

Method used

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  • Medicine application of iron liposome
  • Medicine application of iron liposome
  • Medicine application of iron liposome

Examples

Experimental program
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Embodiment Construction

[0035] In this experiment, iron liposome oral liquid is used to treat anemia in rats with chronic inflammation, and the present invention is illustrated as an example. Including the method of use and the effect obtained.

[0036] 1. Rapid establishment and testing of rat inflammatory anemia model

[0037] 12 SD rats, normal light, natural drinking water and diet. After 48 hours, the hemoglobin level was measured by taking blood from the tip of the tail. After that, 1 ml of blood was drawn from the retro-orbital venous plexus, and 250 μg / kg of LPS normal saline solution was injected intraperitoneally after bloodletting. After 24 hours, blood was taken from the tip of the tail to measure the hemoglobin level to detect whether it was anemic. After the determination of anemia, the rats were randomly divided into two groups, 6 in each group, respectively the normal saline group and the LPS group. The LPS group was injected intraperitoneally with 250 μg / kg LPS in normal saline sol...

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Abstract

The invention discloses a medicine application of iron liposome. By taking animals with chronic inflammation as a model, a brand-new medicine which treats anaemia caused by the dysfunction of the iron absorption of the small intestine to relevant protein molecules and takes the iron liposome as an effective component is provided. The invention takes white rats with inflammatory anaemia as a model, adopts an oral stomach infusion method and compares the curative effect of the iron liposome for the anaemia with that of a chalybeate which is not enveloped by the liposome, and the iron liposome can obviously enhance the levels of the hemoglobin, the blood cell volume, the serum iron and the saturation rate of the transferrin of an organism in a short time, can act as a very good curative effect to the inflammatory anaemia and can not cause injuries to the health of the organism. The iron liposome is obviously superior to the traditional iron-replenished preparation. The invention can be used for treating the anaemia caused by the dysfunction of the iron absorption of the small intestine to the protein molecules because of various known or unknown reasons. Various tablets, capsules, dripping pills, oral liquid and food additives which are taken orally and contain the iron liposome are prepared.

Description

technical field [0001] The invention relates to the pharmaceutical application of the iron liposome, in particular to its application in the preparation of medicines for treating anemia. Background technique [0002] The absorption of iron by the body mainly includes the absorption of inorganic iron and heme iron in food by small intestinal absorptive cells. got a preliminary understanding. The absorption mechanism of inorganic iron in the small intestine is as follows: iron in the food is first reduced to divalent iron by duodenal cytochrome b (duodenal cytochrome b, Dcytb), and the divalent metal ion transporter (divalent metal transporter, DMT1) Under the action, the absorption cells of the small intestinal mucosa take iron into the cells, a part of the iron can be combined with ferritin (ferritin) and stored in the cells, and a part of the iron can be transported out under the transport of ferroportin 1 (FPN1). Small intestinal cells are oxidized to trivalent under the...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61P7/06A23L1/30A23L33/10
Inventor 常彦忠葛兰王惠杰段相林
Owner HEBEI NORMAL UNIV
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