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Agents for intravitreal administration to treat or prevent disorders of the eye

A technology of freeze-drying pharmaceutical preparations and solutions, which can be used in sensory diseases, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as retinal detachment or tearing, blood vessel bleeding, and danger

Inactive Publication Date: 2010-05-26
透明视网膜技术公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of vitreous extraction is very technical and is associated with several significant disadvantages, dangers, and complications
Among the disadvantages, risks and complications, the act of removing the vitreous may further cause detachment or tearing of the retina and / or such removal of the vitreous will further cause bleeding of already fragile blood vessels

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0070] A. Urea preparations

[0071] The following are examples of urea-containing solutions that can be used in the present invention:

Embodiment 1

[0073] Urea USP / NF 4.0%

[0074] Sodium Chloride USP / NF up to 0.9%

[0075] Sterile water for injection USP appropriate amount (Q.S.) 100%

[0076] Solution pH 5.0-7.0

[0077] (PH is adjusted with 0.1N hydrochloric acid / 0.1 sodium hydroxide)

Embodiment 2

[0079] Urea USP / NF 4.0%

[0080] Citric acid USP / NF 0.00007-0.02%

[0081] Sterile Water for Injection USP Q.S. 100%

[0082] Solution pH 5.0-7.0

[0083] (PH is adjusted with 0.1N hydrochloric acid / 0.1 sodium hydroxide)

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PUM

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Abstract

Methods and preparations for treating disorders of the eye and / or causing posterior vitreous disconnection or disinsertion. Preparations containing (a) urea, (b) urea derivatives (e.g., hydroxyurea, thiourea), (c) a non-steroidal anti-inflamatory agent, (d) antimetabolites, (e) urea, urea derivatives, non-enzymatic proteins, nucleosides, nucleotides and their derivatives (e.g., adenine, adenosine, cytosine, cytadine, guanine, guanitadine, guanidinium, thymidine, thimitadine, uradine, uracil, cystine), uric acid, calcium acetal salicylate, ammonium sulfate or other compound capable of causing non-enzymatic dissolution of the hyaloid membrane or (e) any of the possible combinations thereof, are administered to the eye in therapeutically effective amounts.

Description

[0001] This application is a divisional application of the invention patent application with the application number 00807107.1 and the application date of March 2, 2000. field of invention [0002] The present invention relates broadly to pharmaceutical preparations and methods of medical treatment, in particular agents (i.e. urea or urea derivatives, non-steroidal anti-inflammatory drugs (NSAIDS) and antimetabolites). Background of the invention [0003] A. Neovascularization [0004] Neovascularization (or angiogenesis) is the process by which new blood vessels are formed in body tissues. Normal neovascularization is the physiological process by which the body creates and maintains the small blood vessels of the circulatory system. However, pathological or iatrogenic neovascularization is the non-physiological process by which abnormal vascular networks are formed in body tissues or in tumors, leading to certain diseases, traumas or other surgical conditions. [0005] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K31/17A61K47/02A61K47/12A61P27/02A61K31/155A61K31/192A61K31/407A61K45/06
CPCA61K45/06A61K31/192A61K31/17A61K31/407A61K31/155A61P27/02A61P27/06A61P35/00
Inventor D·卡斯蒂莱约斯
Owner 透明视网膜技术公司
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