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Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions and their preparation, can solve problems such as failure to reduce long-term cardiac end-point events, failure to reduce the incidence of patients, etc.

Active Publication Date: 2012-03-14
陶波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recent large-scale clinical studies have shown that interventional therapy did not reduce the incidence of rehospitalization of patients due to symptom recurrence, nor did it reduce the occurrence of long-term cardiac endpoints

Method used

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  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] Embodiment 1: pharmaceutical composition capsule of the present invention

[0171] American ginseng 1kg Salvia 3kg.

[0172] A. Preparation of Salvia miltiorrhiza fat-soluble extract: Take Danshen medicinal material, add 80% ethanol of 8 weight times, reflux and extract at 65° C. for 1.5 hours, filter, leave the dregs for later use, take the filtrate, recover ethanol under low temperature and reduced pressure, and concentrate to Each milliliter is equivalent to 2.0 grams of the original drug, which is the fat-soluble extract of Danshen;

[0173] B. Preparation of the compound water-soluble extract: take Danshen medicinal dregs, mix them with American ginseng medicinal materials, add 10 times the weight of purified water respectively, heat and extract 3 times, each time for 1 hour, filter the extract, merge, and concentrate under reduced pressure to Each milliliter is equivalent to 2.0 grams of the original drug, and the compound water-soluble extract is obtained;

[0...

Embodiment 2

[0176] Embodiment 2: pharmaceutical composition tablet of the present invention

[0177] American ginseng 1kg Salvia 2kg.

[0178] A. Preparation of Danshen fat-soluble extract: take Danshen medicinal material, add 6 weight times of 85% ethanol and extract under reflux at 60°C for 1.8 hours, filter, leave the drug residue for later use, take the filtrate, reclaim ethanol under low temperature and reduced pressure, and concentrate to Each milliliter is equivalent to 1.5 grams of the original drug, that is, the extract of Danshen;

[0179] B. Preparation of the compound water-soluble extract: take Danshen medicinal residues, mix them with American ginseng medicinal materials, add 12 times of purified water by weight respectively, heat and extract 2 times, each time for 1.5 hours, filter the extracts, merge, and concentrate under reduced pressure to Each milliliter is equivalent to 1.5 grams of the original drug, and the compound water-soluble extract is obtained;

[0180] C. P...

Embodiment 3

[0182] Embodiment 3: pharmaceutical composition granule of the present invention

[0183] American ginseng 1kg Salvia 5kg.

[0184] A. Preparation of Salvia miltiorrhiza fat-soluble extract: Take Danshen medicinal material, add 80% ethanol of 8 weight times, reflux and extract at 65° C. for 1.5 hours, filter, leave the dregs for later use, take the filtrate, recover ethanol under low temperature and reduced pressure, and concentrate to Each milliliter is equivalent to 2.0 grams of the original drug, which is the fat-soluble extract of Danshen;

[0185] B. Preparation of the compound water-soluble extract: take Danshen medicinal dregs, mix them with American ginseng medicinal materials, add 10 times the weight of purified water respectively, heat and extract 3 times, each time for 1 hour, filter the extract, merge, and concentrate under reduced pressure to Each milliliter is equivalent to 2.0 grams of the original drug, and the compound water-soluble extract is obtained;

[0...

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Abstract

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicinal composition is prepared by mixing danshen root and American ginseng in a certain proportion. The preparation method comprises the following processes: firstly extracting the danshen root to obtain a fat-soluble extract of the fat-soluble, then preparing a compound composition, finally adding conventional accessories into the extracted purified substances, and preparing conventional dosage forms according to the conventional process. The medicinal composition of the invention can effectively resist acute myocardial infarction and rat infarction myocardial ischemic injury, reduce the myocardial infarction area, improve the tolerability of myocardium to hypoxia, improve the vascular endothelium function, and resist the formulation of cardiovascular and cerebrovascular artery thrombus. The synergistic experiments show that the compatibility of the American ginseng and the danshen root serving as the raw materials of the medicinal composition has synergy, the effect of the medicinal composition is greatly improved compared with that ofthe medicament prepared by using American ginseng or danshen root, and the medicinal composition has the advantages of low toxicity, high safety and good stability.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Angina pectoris of coronary heart disease is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional agitation or other factors increase myocardial oxygen consumption. The pain can often radiate to the left shoulder, neck pharynx or mandible, and can be relieved within a few minutes by rest or nitroglycerin. During the onset of angina pectoris, the electrocardiogram often shows temporary ST segment changes or accompanied by T wave changes, and coronary angiography shows narrowing of the coronary artery lumen. [0003] Coronary heart disease angina pectoris is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 陶波
Owner 陶波
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