Novel human cell growth inhibiting gene THAP11 and application thereof

Abstract

The invention provides a novel human cell growth inhibiting gene and an application of an encoded protein. The gene and the encoded protein are related to the regulation and control of a cell cycle, can inhibit the growth of tumor cells by inhibiting the expression of a proto oncogene c-Myc, and are down-regulated in various tumor tissues, thereby having a close relation with the generation of tumors. The gene and the encoded protein and derivatives thereof can be used for the diagnosis, treatment and drug screening for tumors caused by disordered regulation and control of cell cycles and neurodegenerative diseases and the like.

Description

technical field

[0001] The invention relates to a new human cell growth regulation gene, and also relates to the DNA constituting the gene and the protein coded by the DNA and its application in the diagnosis and treatment of tumors and neurodegenerative diseases. Background of the invention:

[0002] Cell growth is complexly regulated by a variety of genes. As a proto-oncogene, c-Myc plays an important role in the signal regulation network regulating cell proliferation, growth, differentiation and apoptosis. Multiple gene studies have reported that down-regulation of c-Myc can trigger cell growth arrest (Roussel et al., 1991; He et al., 1998). As one of the most important transcription factors, c-Myc is widely expressed in various stages of embryonic development and in tissues with high proliferation ability. The expression level of c-Myc in the resting period of the cell is very low. Under the action of growth factors, the c-Myc protein is synthesized rapidly, and forms ...

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