Nano microsphere preparation used for chemotherapy of tumors and preparation method thereof
A technology of nano-microspheres and preparations, which is applied in the direction of antineoplastic drugs, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as unsatisfactory clinical efficacy, increased systemic toxic and side effects, and large dosage of gemcitabine. , to achieve the effects of prolonged residence time in the body, large toxic and side effects, and large dosage
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Embodiment 1
[0039] Dissolve 20mg albumin in 1mL water for injection, adjust the pH value to 8.5 with 1M NaOH solution, dissolve 1.25mg gemcitabine hydrochloride in 100μL water for injection, adjust the pH value to about 9.0 with 1M NaOH solution, add the drug solution under stirring Add 3.0 mL of ethanol to the albumin solution at a rate of 1.0 mL / min while stirring until blue opalescence is formed. After stirring for 10 min, add 2.5 μL of cross-linking agent glutaraldehyde, and continue stirring for 12 h to promote the cross-linking of nanoparticles Solidified, evaporated to remove ethanol under reduced pressure at 40°C, and freeze-dried to obtain gemcitabine albumin nanospheres.
Embodiment 2
[0041] Dissolve 50mg of albumin and 10mg of gemcitabine hydrochloride in 2mL of normal saline, adjust the pH value to 9.0 with 1M NaOH solution, add 5.0mL of absolute ethanol at a speed of 1.0mL / min while stirring to form a milky colloidal suspension, stir In some cases, 15 μL of glutaraldehyde was added, stirring continuously for 6 hours to promote cross-linking and solidification of albumin nanoparticles, evaporation of ethanol under reduced pressure at 30°C, and freeze-drying to obtain gemcitabine albumin nanoparticles.
Embodiment 3
[0043]Dissolve 100mg of albumin and 10mg of gemcitabine hydrochloride in 2mL of normal saline, adjust the pH value to 9.0 with 1M NaOH solution, add 5mL of acetone solution at a speed of 1.0mL / min under stirring to form a milky colloidal suspension, under stirring Add 30 μL of glutaraldehyde, stir continuously for 8 hours to promote cross-linking and solidification of albumin nanoparticles, evaporate acetone under reduced pressure at 30° C., and freeze-dry to obtain gemcitabine albumin nanoparticles.
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