34results about How to "Strong molecular weight" patented technology

The invention relates to strong-hydrophobic porous carbon nanofiber and a preparation method thereof, and belongs to the technical field of porous carbon fiber. The preparation method comprises the following steps: adding thermosetting phenol resin and high molecular weight linear polymers into organic solvent with two proportions to be mixed until the thermosetting phenol resin and the high molecular weight linear polymers are fully dissolved, performing electrostatic spinning on the solution to form phenolic resin fiber, and carrying out curing and carbonizing to obtain the hydrophobic porous carbon nanofiber. The porous carbon nanofiber and the preparation method have the advantages as follows: the diameter, the pore structure and the hydrophobicity of the fiber can be adjusted and controlled through the change of the proportions of the solvent, the prepared carbon nanofiber has good flexibility, a developed pore structure and strong hydrophobicity, and is more conductive to practical application.

The invention discloses a gaseous-phase in-situ polymerization method for preparing an ultra-high molecular weight polyethylene graphene composite material. The method comprises the following steps of: reacting graphene which serves as a catalyst carrier with a transition metal compound to prepare a solid catalyst under a certain conditions, and reacting to prepare the ultra-high molecular weight polyethylene graphene composite material under the gaseous-phase conditions without a diluent. Graphene serves as the catalyst carrier and a reinforcing filler and is reacted under the gaseous-phase conditions, so that the polymerization activity can be improved through catalyst loading; and graphene in the composite material is uniformly dispersed, so that the composite material has excellent performance and particularly high impact resistance, and the problems that the traditional composite material is subjected to brittle rupture and is ineffective in long-term use process are solved.

The invention relates to antioxidant peptide sourced from limnonectes fragilis as well as a gene and an application thereof and belongs to the technical field of biomedicine. The primary structural sequences of three antioxidant peptides Fragilin-A1, Fragilin-B2 and Odorranain-Q-Lf which are sourced from the limnonectes fragilis, have the encoding genes obtained through a gene clone way, are obtained through a chemical synthesis method and respectively contain 15 amino acid residues, 12 amino acid residues and 21 amino acid residues; the molecular weight of each of the three antioxidant peptides is respectively 1720.95Da, 1464.66Da and 2597.18Da; an isoelectric point of each of the three antioxidant peptides is respectively 8.04, 8.75 and 9.53. The three antioxidant peptides are strong in antioxidant activity, small in molecular weight, simple in structure, low in hemolytic activity and simple in preparation method. When the antioxidant peptide is applied to antioxidant medicines, foods or cosmetic additives, the antioxidant effect of the medicines, the foods or the cosmetic additives can be improved, and the application prospect is promising.

The invention belongs to the technical field of the pharmacy of medicine, which relates to a gemcitabine-albumin nano microsphere preparation used for the chemotherapy of the tumors of pancreatic cancer and the like and a preparation method thereof. The invention uses an ethanol precipitation-glutaric dialdehyde crosslinking denaturation method to prepare a slow-release gemcitabine biodegradable albumin nano microsphere. By animal experiments, the result confirms that the invention can obviously enhance the slow-release property and the tissue retention property of the medicine, enhances the concentration of gemcitabine in tumors and other target organs effectively, prolongs the effective acting time of the gemcitabine and reduces the side effect of the medicine. The nano microsphere can be used for the chemotherapy and the interventional chemotherapy of pancreatic cancer and non-small cell lung cancer and is suitable for the venous chemotherapy, the arterial interventional treatment, the local tumor injection interstitial chemotherapy, the celiac chemotherapy and the oral chemotherapy of tumor patients with gemcitabine adaptive diseases.

The invention relates to a preparation method of a red mud sinking agent, which comprises the following steps of mixing acrylamide, acrylic acid and urea with deionized water in weight percent, cooling and regulating the pH value to end the material preparation; mixing the ingredients, chelating agent and chain transfer agent in a reaction kettle, sequentially adding a third section oxidant, a second section oxidant, a first section oxidant, a reducer and an auxiliary reducer in nitrogen introducing process, continuously introducing nitrogen, and than stopping nitrogen introduction, sealing, and carrying out insulation polymerization reaction; opening a reaction kettle bottom valve after being placed, pressing out a rubber block by compressed air and disintegrating the rubber block into colloidal particles by a granulator; and hydrolyzing the colloidal particles, and preparing a product through treatments of granulation, drying, crushing, screening and packaging. The aluminum oxide plant red mud sinking agent has the advantages of high molecular weight, fast dissolving speed, high hydrolysis degree and low cost.

The invention discloses an anti-human serum albumin single-chain antibody and a method for connecting polypeptide medicine with the nitrogen terminal of the antibody. A VL chain region has a complementary identification region (CDR) which has the following amino acid sequences of CDRs: N-SEQ-08 of CDR1, N-SEQ-09 of CDR2 and N-SEQ-010 of CDR3; a VH chain region has a complementary identification region which has the following amino acid sequences of CDRs: N-SEQ-05 of CDR1, N-SEQ-06 of CDR2 and N-SEQ-07 of CDR3; the VH chain takes the amino acid sequence shown as N-SEQ-02 as an expression form; the VH chain takes the amino acid sequence shown as N-SEQ-04 as an expression form; and the VH chain region and the VL chain region are connected through a protein hinge shown as N-SEQ-01 or N-SEQ-03. The single-chain antibody has small molecular weight, strong specificity, weak immunogenicity and high water solubility and is easily produced on a large scale in a fermentation mode. The invention also discloses a composition prepared from the single-chain antibody; and the medicine can effectively prolong the half-life period of polypeptide biological medicines.

The invention provides a high-temperature-resistant abrasion-resistant non-stick pan coating, a preparation method and a non-stick pan with the same. Nickel plating is conducted on the surface of a metal pan base body through the electrochemical method. Under the action of a magnetic field, a formed surface nickel layer is uniform and flat, and accordingly it is guaranteed that the subsequent coating is flat and uniform. Secondly, an annular structure in a poly(aryl ether nitrile ketone) molecular main chain makes the coating have good high temperature resistance, a molecular structure contains strong-polarity groups, namely nitrile groups, and the nitrile groups generate strong action force on the surface of a metal base material. Thirdly, under the action of irradiation, a silane coupling agent KH792 and poly(aryl ether nitrile ketone) have grafting reaction, and heat resistance is further improved, so that organic solvent molecules cannot permeate into the metal base material, stability is improved, the organic solvent molecules and the surface of the metal base material are connected in a strong chemical bond mode, and adhesion of the coating is greatly improved. Accordingly, the high-temperature-resistant anti-wear non-stick pan coating prepared through the method does not contain fluorine and is resistant to high temperature, abrasion and scratching.

The invention provides a modified antibacterial peptide C-CM8 of a Chelonia mydas antibacterial peptide and a preparation method and application thereof. The N end of the modified antibacterial peptide is an alpha helix, the C end is a polypeptide of an irregular structure, the modified antibacterial peptide contains 17 amino acid residues, the molecular weight is 1998.37Da, and the isoelectric point is 12.60. The modified antibacterial peptide C-CM8 has broad-spectrum and efficient antibacterial activity and extremely high anti-inflammatory activity, has the advantages of being small in molecular weight, simple in structure, low in hemolytic activity, simple in preparation method and the like, is expected to become a novel efficient antibacterial drug, has wide development and application prospects, and is especially used for preparing antibacterial drugs or compositions, bacteria growth inhibiting drugs or compositions, anti-inflammatory drugs or compositions, preservatives, animal feed additives or cosmetic additives.

The invention discloses low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate and a preparation method thereof. The low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate has a structural formula as shown in the specification. The degree of functionality of the low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate is 6-9, the viscosity is 300-2000mPa.s, and the molecular weight is 750-2500, so that the low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate has very high reactivity, lower viscosity, high molecular weight, low migration, high curing efficiency, low volume contraction rate, good adhesive force and adjustable flexibility, and a prepared coating is good in impact resistance and strong in adhesive force; and the preparation method disclosed by the invention is simple and easy to control, and an obtained product is high in purity and good in performance.

The invention provides a method for synthesizing polyolefin from alpha-olefin prepared from coal and a product. The method comprises the following step: under the action of a catalyst containing a fluorinated alcohol load and a cocatalyst, carrying out polymerization reaction on the alpha-olefin prepared from the coal. The catalyst containing the fluorinated alcohol load takes magnesium halide as a carrier, an aluminum alkyl compound as an activating agent and fluorinated alcohol as an electron donor to load a transition metal compound; and the fluorinated alcohol is an aliphatic fluorine-containing alcohol compound or monohydric alcohol. The polymerization method disclosed by the invention can be used for mildly and efficiently polymerizing C5 and above alpha-olefin to obtain high-molecular-weight and high-branching-degree polyolefin, the method is simple to operate, and the product is easy to obtain. According to the method disclosed by the invention, the alpha-olefin prepared from coal is used as a raw material, a single component does not need to be separated, only simple treatment is needed, the weight-average molecular weight of the obtained product is not less than 150 thousand Daltons, and the branching degree is not less than 30 branched chains/1000C.

The invention discloses a modified tripentaerythritol acrylic ester with low viscosity, high reactivity and shrunk volume as well as a preparation method thereof. The structural formula of the modified tripentaerythritol acrylic ester with low viscosity, high reactivity and shrunk volume is shown in specification. The modified tripentaerythritol acrylic ester has degree of functionality of 8-12, viscosity of 800-4000 m Pa.s and molecular weight of 1000-4000, and the modified tripentaerythritol acrylic ester also has very high reactivity, low viscosity, low migration of high molecular weight, high solidification efficiency, low volume shrinkage, excellent adhesive force, adjustable softness and adjustable flexibility. A prepared coating is good in impact resistance and strong in adhesive force. The preparation method is simple and easy to control, and the obtained product is high in purity and good in properties.

The invention discloses low-viscosity high-reactivity low-volume-shrinkage modified pentaerythritol acrylate and a preparation method thereof. The low-viscosity high-reactivity low-volume-shrinkage modified pentaerythritol acrylate has a structural formula as shown in the specification. The functionality of the low-viscosity high-reactivity low-volume-shrinkage modified pentaerythritol acrylate is 4-6, the viscosity is 40-70mPa.s, and the molecular weight is 750-2500, so that the low-viscosity high-reactivity low-volume-shrinkage modified pentaerythritol acrylate is very high in reactivity, low in viscosity, high in molecular weight, low in migration, high in curing efficiency, low in volume shrinkage ratio, good in adhesive force and adjustable in flexibility, and a prepared paint is good in impact resistance and strong in adhesive force. The preparation method disclosed by the invention is simple and easy to control, and the obtained product is high in purity and good in performance.

The invention provides a gas generating agent of a fire-extinguishing device and a preparation method thereof and relates to the technical field of fire fighting and fire extinguishing. The gas generating agent comprises a main component and auxiliary components, wherein the main component is prepared by the following materials in percent by weight: 60-70% of potassium nitrate, 10-20% of melamine and no less than 5% of foaming agent; and the auxiliary components comprise the following materials in percent by weight: 6-12% of adhesive and no more than 5%. The gas generating agent provided by the invention has the advantages that the components are simple, the cost is low, the generated gas is stable in pressure and strong in continuity, and the gas generation amount is large, so that the fire extinguishing efficiency of the fire-extinguishing device is high and the like.