34results about How to "Strong molecular weight" patented technology

The invention belongs to the technical field of the pharmacy of medicine, which relates to a gemcitabine-albumin nano microsphere preparation used for the chemotherapy of the tumors of pancreatic cancer and the like and a preparation method thereof. The invention uses an ethanol precipitation-glutaric dialdehyde crosslinking denaturation method to prepare a slow-release gemcitabine biodegradable albumin nano microsphere. By animal experiments, the result confirms that the invention can obviously enhance the slow-release property and the tissue retention property of the medicine, enhances the concentration of gemcitabine in tumors and other target organs effectively, prolongs the effective acting time of the gemcitabine and reduces the side effect of the medicine. The nano microsphere can be used for the chemotherapy and the interventional chemotherapy of pancreatic cancer and non-small cell lung cancer and is suitable for the venous chemotherapy, the arterial interventional treatment, the local tumor injection interstitial chemotherapy, the celiac chemotherapy and the oral chemotherapy of tumor patients with gemcitabine adaptive diseases.

The invention discloses a bisphenol A isocyanate phenolic resin and a preparation method thereof. In the method, hexamethylene diisocyanate is used as a graft monomer and dibutyltin dilaurate is used as a catalyst, so that the hexamethylene diisocyanate is Under the action, the graft is formed, so that the originally rigid bisphenol A formaldehyde novolac resin and hexamethylene diisocyanate, because the isocyanate is easy to react with the polyhydroxy compound, and the reactivity of the isocyanate is very high, it can be used at room temperature. Chemical reactions can occur, which improves the low reactivity of bisphenol A formaldehyde phenolic resin at room temperature, the preparation process is complex, and high energy consumption is required during the reaction; the preparation process is simple, and the bulk reaction is used to make it react more fully High, the prepared bisphenol A isocyanate phenolic resin, because the isocyanate group replaces the hydroxyl group on the bisphenol A formaldehyde phenolic resin, it weakens its hydrophilicity and increases its waterproof performance.

The invention provides a gas generating agent of a fire-extinguishing device and a preparation method thereof and relates to the technical field of fire fighting and fire extinguishing. The gas generating agent comprises a main component and auxiliary components, wherein the main component is prepared by the following materials in percent by weight: 60-70% of potassium nitrate, 10-20% of melamine and no less than 5% of foaming agent; and the auxiliary components comprise the following materials in percent by weight: 6-12% of adhesive and no more than 5%. The gas generating agent provided by the invention has the advantages that the components are simple, the cost is low, the generated gas is stable in pressure and strong in continuity, and the gas generation amount is large, so that the fire extinguishing efficiency of the fire-extinguishing device is high and the like.

The invention discloses low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate and a preparation method thereof. The low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate has a structural formula as shown in the specification. The degree of functionality of the low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate is 6-9, the viscosity is 300-2000mPa.s, and the molecular weight is 750-2500, so that the low-viscosity high-reactivity low-volume-contraction modified dipentaerythritol acrylate has very high reactivity, lower viscosity, high molecular weight, low migration, high curing efficiency, low volume contraction rate, good adhesive force and adjustable flexibility, and a prepared coating is good in impact resistance and strong in adhesive force; and the preparation method disclosed by the invention is simple and easy to control, and an obtained product is high in purity and good in performance.

The invention discloses an anti-human serum albumin single-chain antibody and a method for connecting polypeptide medicine with the nitrogen terminal of the antibody. A VL chain region has a complementary identification region (CDR) which has the following amino acid sequences of CDRs: N-SEQ-08 of CDR1, N-SEQ-09 of CDR2 and N-SEQ-010 of CDR3; a VH chain region has a complementary identification region which has the following amino acid sequences of CDRs: N-SEQ-05 of CDR1, N-SEQ-06 of CDR2 and N-SEQ-07 of CDR3; the VH chain takes the amino acid sequence shown as N-SEQ-02 as an expression form; the VH chain takes the amino acid sequence shown as N-SEQ-04 as an expression form; and the VH chain region and the VL chain region are connected through a protein hinge shown as N-SEQ-01 or N-SEQ-03. The single-chain antibody has small molecular weight, strong specificity, weak immunogenicity and high water solubility and is easily produced on a large scale in a fermentation mode. The invention also discloses a composition prepared from the single-chain antibody; and the medicine can effectively prolong the half-life period of polypeptide biological medicines.

The invention relates to antioxidant peptide sourced from limnonectes fragilis as well as a gene and an application thereof and belongs to the technical field of biomedicine. The primary structural sequences of three antioxidant peptides Fragilin-A1, Fragilin-B2 and Odorranain-Q-Lf which are sourced from the limnonectes fragilis, have the encoding genes obtained through a gene clone way, are obtained through a chemical synthesis method and respectively contain 15 amino acid residues, 12 amino acid residues and 21 amino acid residues; the molecular weight of each of the three antioxidant peptides is respectively 1720.95Da, 1464.66Da and 2597.18Da; an isoelectric point of each of the three antioxidant peptides is respectively 8.04, 8.75 and 9.53. The three antioxidant peptides are strong in antioxidant activity, small in molecular weight, simple in structure, low in hemolytic activity and simple in preparation method. When the antioxidant peptide is applied to antioxidant medicines, foods or cosmetic additives, the antioxidant effect of the medicines, the foods or the cosmetic additives can be improved, and the application prospect is promising.

The invention discloses an anti-human serum albumin single-chain antibody and a method for connecting polypeptide drugs to a carbon end of the anti-human serum albumin single-chain antibody. According to the anti-human serum albumin single-chain antibody a, a VH (Variable fragments of heavy chain) chain area of the single-chain antibody has a CDR (Complementarity-Determining Region) amino acid sequence of a complementary recognition domain, shown as C-SEQ (Sequence)-05, C-SEQ-06 and C-SEQ-07; a VL (Variable fragments of light chain) chain area of the single-chain antibody has a CDR amino acid sequence of a complementary recognition domain, shown as C-SEQ-08, C-SEQ-09 and C-SEQ-010; and the amino sequence of the single-chain antibody and the amino sequences of polypeptide drugs are connected from a nitrogen end of the single-chain antibody by a protein linking hinge shown as C-SEQ-01 or C-SEQ-03. The single-chain antibody disclosed by the invention has small molecular weight, high antibody specificity, weak immunogenicity and good water solubility, and is easily massively produced through a fermenting way. The invention also discloses a composition manufactured by using the single-chain antibody disclosed by the invention; and the composition can effectively prolong a half-life period of the polypeptide drugs.

The invention discloses a class of phenanthroimidazole electroluminescence material with circularly polarized light emission, a preparation method and application thereof. The structure of the described phenanthroimidazole electroluminescent material with circularly polarized luminescence is shown in formula (I), and the material: (1) has circularly polarized luminescent properties, and prepares a CP-OLED device as a light-emitting layer, which can improve the efficiency of the device. (2) It has localized hybrid charge transfer state performance, which can effectively use triplet excitons to improve the utilization rate of excitons and improve the electroluminescence performance of devices; ( 3) The luminescent material CPPI has a large degree of conjugation and strong rigidity, which can improve the thermal stability of the material, increase the radiation transition rate of the material, and improve its luminous efficiency; (4) The luminescent material CPPI has a large molecular weight and has a good Solubility, solution processing technology can be used to prepare large-area flexible display devices, which has great development potential and prospects in the field of organic electronic display.

The invention discloses a soybean protein-based double-crosslinked self-healing supramolecular sulfur cathode aqueous binder, a preparation method and application thereof. The binder is prepared from hydrolyzed soybean protein, a small molecule cross-linking agent and a copolymer monomer through a radical copolymerization method. The binder has a three-dimensional network cross-linked structure and the characteristics of raw materials make it have strong bond strength, excellent self-healing performance, strong lithium polysulfide adsorption capacity and biodegradability. When the binder is applied in a lithium-sulfur battery, the cycle life of the battery can be effectively extended, the rate performance of the battery can be optimized, and the specific capacity of the battery can be improved. The present invention uses the free radical copolymerization method to connect the hydrolyzed soybean protein and the copolymer through the chemical crosslinking of the small molecule crosslinking agent and the hydrogen bond existing between the former two in a physical crosslinking manner to obtain a three-dimensional network structure of adhesives. The double cross-linking effect inside the adhesive prepared by the method endows the adhesive with strong bonding ability and self-healing performance.

The invention provides a high-temperature-resistant abrasion-resistant non-stick pan coating, a preparation method and a non-stick pan with the same. Nickel plating is conducted on the surface of a metal pan base body through the electrochemical method. Under the action of a magnetic field, a formed surface nickel layer is uniform and flat, and accordingly it is guaranteed that the subsequent coating is flat and uniform. Secondly, an annular structure in a poly(aryl ether nitrile ketone) molecular main chain makes the coating have good high temperature resistance, a molecular structure contains strong-polarity groups, namely nitrile groups, and the nitrile groups generate strong action force on the surface of a metal base material. Thirdly, under the action of irradiation, a silane coupling agent KH792 and poly(aryl ether nitrile ketone) have grafting reaction, and heat resistance is further improved, so that organic solvent molecules cannot permeate into the metal base material, stability is improved, the organic solvent molecules and the surface of the metal base material are connected in a strong chemical bond mode, and adhesion of the coating is greatly improved. Accordingly, the high-temperature-resistant anti-wear non-stick pan coating prepared through the method does not contain fluorine and is resistant to high temperature, abrasion and scratching.

A refining method of ginkvone is carried out by dissolving GBE into 60% alcohol monohydrate in proportion of 1:200mass ratio, first super-filtering the GBE solution at 0.05-0.3Mpa and 10-50 DEG C, collecting filtrate, decompress concentrating the collected filtrate, dissolving residual steamed into anhydrous ethanol in proportion of 1:50 mass ratio, adding beta-cyclodextrin or modified beta-cyclodextrin into the solution obtained in proportion of flavone:beta-cyclodextrin or modified beta-cyclodextrin=1:9-1:1, reacting in water bath at 20-90 DEG C for 15mins-5hrs, reacting at normal temperature for 30mins-24hrs, second super-filtering the reactant at 0.05-0.3Mpa and 10-50 DEG C, and collecting the concentrated liquid to obtain the final product. It is simple, has short production period and more content and saves raw materials.

The present invention relates to a new kind anti-embolism linear small-peptide molecule developed based on the protein structure and function research. It has the amino acid sequence of X-Gly-Asp-Y, powerful activity of inhibiting thrombocyte aggregation, high stability, good specificity and selectivity, small molecular weight, to immunogenicity, simple structure, low cost and easy synthesis. Owing to the effective binding with thrombocyte GPIIbIIIa and competitive inhibition of the combination between fibrinogen and thrombocyte, the small peptide may be used as thrombocyte inhibitor in basic research and clinical application.