Dimer citrinin compounds and preparation and use thereof

A kind of compound and application technology, applied in the field of preparing cell proliferation inhibitor
CN101735236AInactive Publication Date: 2010-06-16OCEAN UNIV OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OCEAN UNIV OF CHINA
Publication Date
2010-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation method and a use of two dimer citrinin compounds. The dimer citrinin compounds with novel structures are produced by adopting Penicillium Citrinum HGY1-5 in samples collected from a crater. Tests prove that the compounds can be used as a cell proliferation inhibitor, an apoptosis inducer or an anti-tumor agent.
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Description

Technical field:

[0001] The present invention relates to a method for producing dimeric citrinins by using Penicillium citrinum HGY1-5 (Penicillium citrinum HGY1-5) (preservation number: CCTCC M208170, preservation date: October 27, 2008); the present invention also relates to Use of the compounds in the preparation of cell proliferation inhibitors, apoptosis inducers or antitumor agents. Background technique:

[0002] Citrinin is an active polyketide compound produced by Penicillium citrinum or some Aspergillus sp., and five dimers have been reported, but the five six-membered rings are fused to each other The formation of novel citrinin dimers has not been reported. The inventors have learned from studies that the crude extract of the liquid fermentation product of Penicillium citrinum HGY1-5 (Penicillium citrinum HGY1-5) (preservation number: CCTCC M 208170) has good cell proliferation inhibition and cell apoptosis after ultrasonic crushing. Death-inducing activity, and...

Claims

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