Method for preparing polyoxovanadium borate

A technology of poly-vanadium borate and boric acid, which is applied in the direction of borate and boron oxide, can solve the problems of low bioavailability, large dose required, toxic and side effects, etc., and achieve the effect of low energy consumption

Inactive Publication Date: 2010-06-23
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, inorganic vanadate has high toxicity, low fat solubility, low bioavailability, and large dosage, so its absorption and utilization rate in organi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The first step, put 1.25mmol boric acid, 0.35mmol sodium metavanadate, 1.25mmol tetramethylammonium bromide and 1.25mmol ethylenediamine into a glass tube with one end sealed, add water dropwise until the substance becomes a paste, and mix well , freeze the bottom with liquid nitrogen, evacuate, and seal the tube.

[0014] In the second step, the material in the tube was mixed evenly on the tube wall, and heated at 90°C for 4 days to obtain green crystals.

[0015] The third step is to open the tube, flush out the crystals with a mixed solution of ethanol and ether with a volume ratio of 1:1, wash them in a glass sand core funnel, filter them with suction, and dry them to obtain the product.

Embodiment 2

[0017] The first step, put 1.25mmol boric acid, 0.35mmol sodium metavanadate, 2.0mmol tetramethylammonium bromide and 2.0mmol ethylenediamine into a glass tube with one end sealed, add water dropwise until the substance becomes a paste, and mix well , freeze the bottom with liquid nitrogen, evacuate, and seal the tube.

[0018] The second step is to mix the material in the tube onto the tube wall and heat it at 90°C for 7 days to obtain green crystals.

[0019] The third step is to open the tube, flush out the crystals with a mixed solution of ethanol and ether with a volume ratio of 1:1, wash them in a glass sand core funnel, filter them with suction, and dry them to obtain the product.

Embodiment 3

[0021] The first step, put 1.25mmol boric acid, 0.35mmol sodium metavanadate, 1.75mmol tetramethylammonium bromide and 1.75mmol ethylenediamine into a glass tube with one end sealed, add water dropwise until the substance becomes a paste, and mix well , freeze the bottom with liquid nitrogen, evacuate, and seal the tube.

[0022] The second step is to mix the material in the tube onto the tube wall and heat it at 110°C for 5 days to obtain green crystals.

[0023] The third step is to open the tube, flush out the crystals with a mixed solution of ethanol and ether with a volume ratio of 1:1, wash them in a glass sand core funnel, filter them with suction, and dry them to obtain the product.

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PUM

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Abstract

The invention discloses a method for preparing polyoxovanadium borate, which comprises the following steps of: putting boric acid and sodium metavanadate into a glass tube with one sealed end; adding tetramethylammonium bromide and ethylenediamine into the glass tube; adding water dropwise into the glass tube until the substances in the tube become paste; mixing the substances uniformly; freezing the substances in the tube by using liquid nitrogen; and vacuumizing and sealing the tube; and heating the tube for 4 to 7 days at the temperature of between 90 and 150 DEG C or putting the tube in the sun to be irradiated for 3 to 14 days to obtain green hexagonal crystal grain polyoxovanadium borate. The method has the advantage of low energy consumption due to the adoption of low-temperature solvent thermochemical reaction or photochemical reaction.

Description

technical field [0001] The invention relates to the field of inorganic clusters, in particular to a preparation method of polyvanadium borate. Background technique [0002] As an essential trace element for the human body, vanadium plays a very important role in the metabolism of glucose. Research has found that the complexes of inorganic vanadate and vanadium have good insulin-like activity. At present, a few vanadium compounds have been put into clinical trial stage. However, inorganic vanadate has high toxicity, low fat solubility, low bioavailability, and large dosage, so its absorption and utilization rate in organisms is low, and a large amount of use has great toxic and side effects, thus affecting its use in the human body. Wide application in the pharmaceutical field. In view of this, it is very important to improve the bioavailability of vanadium compounds and reduce its toxicity. The common method to solve these problems is to select suitable ligands to improve ...

Claims

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Application Information

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IPC IPC(8): C01B35/12
Inventor 单永奎张其颖杨琼金忠敏
Owner EAST CHINA NORMAL UNIV
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