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Drug composition of ligustrazine hydrochloride and benzyl alcohol and preparation method thereof

A technology of ligustrazine hydrochloride and its composition, which is applied in the pharmaceutical composition of ligustrazine hydrochloride and benzyl alcohol and its preparation field, can solve the problems of strong irritation and poor patient tolerance, and reduce irritation and vein irritation , the effect of improving tolerance

Inactive Publication Date: 2010-06-30
HAINAN SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of too strong irritation and poor patient tolerance in the clinical application of the existing Ligustrazine Hydrochloride Injection, the inventors have surprisingly found that the pharmaceutical composition of Ligustrazine Hydrochloride and Benzyl Alcohol is made from a large amount of screening work. Injections are less irritating for the treatment of cerebrovascular system diseases, which can greatly improve the tolerance of patients and improve the safety of clinical medication

Method used

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  • Drug composition of ligustrazine hydrochloride and benzyl alcohol and preparation method thereof
  • Drug composition of ligustrazine hydrochloride and benzyl alcohol and preparation method thereof

Examples

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Effect test

Embodiment 1

[0038] 1. Prescription

[0039] prescription 1

[0040] Ligustrazine Hydrochloride 120g

[0041] Benzyl alcohol 5g

[0042] Mannitol 23g

[0043] Sodium Chloride 15g

[0044] Add water for injection to 2000mL

[0045]

[0046] A total of 1000 pieces were prepared

[0047] prescription 2

[0048] Ligustrazine hydrochloride 80g

[0049] Benzyl alcohol 1.5g

[0050] Mannitol 28.5g

[0051] Sodium Chloride 15g

[0052] Add water for injection to 2000mL

[0053]

[0054] A total of 1000 pieces were prepared

[0055] 2. Preparation method:

[0056] Weigh ligustrazine hydrochloride, benzyl alcohol, mannitol and sodium chloride according to the prescription, put them in a container, add 90% water for injection of the prescription, heat to 35°C, stir to dissolve, and add water to 2000mL;

[0057] Add 0.02% activated carbon for needles to the above solution, stir well at room temperature, filter to remove carbon, a...

Embodiment 2

[0060] 1. Prescription

[0061] prescription 1

[0062] Ligustrazine hydrochloride 80g

[0063]Benzyl alcohol 3g

[0064] Mannitol 137g

[0065] Add water for injection to 2000mL

[0066]

[0067] A total of 1000 sticks were prepared

[0068] Prescription 2

[0069] Ligustrazine Hydrochloride 120g

[0070] Benzyl alcohol 6g

[0071] Mannitol 204g

[0072] Add water for injection to 3000mL

[0073]

[0074] A total of 1000 sticks were prepared

[0075] 2. Preparation process:

[0076] Weigh ligustrazine hydrochloride, benzyl alcohol and mannitol according to the prescription, put them in a container, add 60% of the prescription amount of water for injection, heat to 30°C, stir to dissolve, add water to 3000mL;

[0077] Add 0.3% active carbon for needles to the above solution, stir well at room temperature, filter to remove carbon, and then fine filter with a 0.22 μm microporous membrane to measure the content...

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Abstract

The invention belongs to the technical field of medicine, and discloses a drug composition of ligustrazine hydrochloride and benzyl alcohol and a preparation method thereof. The weight ratio of the ligustrazine hydrochloride and the benzyl alcohol is 1:0.01 to 0.1, and an injection is prepared by the drug composition and pharmaceutically acceptable excipients; and the excipients are selected from one or more of mannitol, sorbitol, low-molecular-weight dextran or sodium chloride. The drug composition can be used for treating cerebral vascular diseases, overcomes the defects that the ligustrazine hydrochloride injection has greater irritation in the process of clinical administration in the prior art, and is favorable for expanding clinical medication.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition of ligustrazine hydrochloride and benzyl alcohol and a preparation method thereof. 2. Background technology [0002] Ligustrazine Hydrochloride is 2,3,5,6-tetramethylpyrazine hydrochloride dihydrate, which is a hydrochloride of an alkaloid monomer extracted from the traditional Chinese medicine Chuanxiong. It has been synthesized artificially. . Ligustrazine hydrochloride is a blood-activating and stasis-removing drug, which has anti-platelet aggregation effect and depolymerization effect on aggregated platelets. It can also dilate small arteries, improve microcirculation and increase cerebral blood flow. It is clinically used for ischemic cerebrovascular diseases, such as: insufficient cerebral blood supply, cerebral thrombosis, cerebral embolism and other ischemic vascular diseases such as coronary heart disease, vasculitis, etc. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4965A61K47/10A61K9/19A61P9/10
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner HAINAN SIHUAN PHARMA
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