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New application of ginsenoside Rd in preparation of colitis treatment medicament

A technology of ginsenoside and colitis, applied in the field of ginsenoside Rd in the preparation of drugs for the treatment of colitis, to achieve the effect of reliable evaluation, unique thinking, and less absorption

Inactive Publication Date: 2010-08-04
LANZHOU UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, drugs with anti-inflammatory effects (such as acetylsalicylic acid) do not necessarily have the effect of treating ulcerative colitis, and there is no report about the research on ginsenoside Rd treating ulcerative colitis in rats at home and abroad, and experiments are still needed. confirmed

Method used

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  • New application of ginsenoside Rd in preparation of colitis treatment medicament
  • New application of ginsenoside Rd in preparation of colitis treatment medicament
  • New application of ginsenoside Rd in preparation of colitis treatment medicament

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1: Dose-effect relationship and mechanism of action of ginsenoside Rd in treating acute ulcerative colitis in rats

[0024] 1. Materials and methods

[0025] 1.1 Drugs and animals Wistar rats, weighing 180-200g, Purchased from the Experimental Animal Center of Lanzhou University, the animal certificate number: Medical Dynamic Zidi SCXK (Gan) 2009-0004. Ginsenoside Rd (purity: ≥95%, the preparation method refers to the published patent: "Compound (1), its extraction method and pharmaceutical composition containing the compound", authorized announcement number: CN1176101C): Guangdong Tahoe Biopharmaceuticals Co., Ltd. batch number: 080312; Sulfasalazine, a product of Shanghai Xinyi Jiahua Co., Ltd., batch number: 081013.

[0026] 1.2 The main reagent 2,4,6-trinitrobenzenesulfonic acid solution (2,4,6-Trinitrobenzenesulfonic acid solution, TNBS) was purchased from Sigma Company, 5% (W / V) aqueous solution, product number P2297-10ML, batch number 20070315); Absol...

Embodiment 2

[0145] Embodiment 2: Ginsenoside Rd treats acute ulcerative colitis rat optimal route of administration

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Abstract

The invention relates to application of ginsenoside Rd in preparation of a colitis treatment medicament, in particular to the application of the ginsenoside Rd in the preparation of an ulcerative colitis treatment medicament. Tests prove the application of the ginsenoside Rd in the preparation of the colitis treatment medicament. The application of the ginsenoside Rd in the preparation of the colitis treatment medicament is that in the preparation of the ulcerative colitis treatment medicament. The application of the ginsenoside Rd in the preparation of the colitis treatment medicament is that in the preparation of nonbacterial chronic colitis treatment medicament. The application of the ginsenoside Rd in the preparation of the colitis treatment medicament is that of ginsenoside Rd oral preparation in the preparation of the ulcerative colitis treatment medicament. By utilizing the characteristics that the ginsenoside Rd is difficult to absorb and mainly enters colon and combining a strong anti-inflammatory effect of the ginsenoside Rd, the application of ginsenoside Rd in preparation of a colitis treatment medicament fully displays the colitis treatment effect of the ginsenoside Rd, discloses the treatment value of an antioxidant for colitis, and has a novel conception.

Description

Technical field: [0001] The present invention mainly relates to the use of ginsenoside Rd in the preparation of drugs for treating colitis. In particular, it relates to the use of ginsenoside Rd in the preparation of medicines for treating ulcerative colitis. Background technique: [0002] Ulcerative colitis (UC) is a chronic inflammation of the colon with unknown etiology and pathogenesis. Abdominal pain, diarrhea, mucus and blood are the main clinical symptoms. Acute fulminant UC has a high mortality rate, chronic persistent type has a high rate of canceration, and is prone to recurrent attacks. Currently, there is no specific drug, so it is listed by the World Health Organization as one of the modern intractable diseases. The incidence of this disease is relatively high in European and American countries, and the prevalence rate is 0.4‰~1‰. There is no accurate statistical report data in China, but it has shown an obvious increasing trend in recent years. Due to the att...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/00A61P1/04
Inventor 吴勇杰黄艳辉范福林
Owner LANZHOU UNIVERSITY
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