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Micro-fluidic chip-based capillary electrophoresis and graphite furnace atomic absorption online coupling interface device

A technology of microfluidic chip and capillary electrophoresis, which is applied in the direction of measuring devices, material analysis through electromagnetic means, instruments, etc., to achieve the effect of low operating cost, easy operation and high resolution

Inactive Publication Date: 2010-08-04
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the limited sample volume of graphite tubes (less than 50 μl) and the "non-flow" of graphite furnaces are the main obstacles to the online coupling of ETAAS with chromatographic separation techniques

Method used

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  • Micro-fluidic chip-based capillary electrophoresis and graphite furnace atomic absorption online coupling interface device
  • Micro-fluidic chip-based capillary electrophoresis and graphite furnace atomic absorption online coupling interface device

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Embodiment 1

[0017] Such as figure 1 As shown, the online connection interface device of the present invention includes: a microfluidic chip, a small hole is punched at the outlet 4 of the chip separation channel, connected with the external capillary 5, and firmly bonded with glue. The other end of the externally connected capillary 5 is inserted into the thermal spray tube 6, the front end of the thermal spray tube is provided with a modification liquid inlet 7, the thermal spray tube is covered with a carrier gas tube 9, and the front end of the carrier gas tube is provided with a carrier gas inlet 8, the carrier gas tube The outer movable suit circulating water cooling jacket 12 is provided with a cooling water inlet 10 and a cooling water outlet 11 on the circulating water cooling jacket.

[0018] A section of hollow graphite cone 13 is fixedly installed outside the carrier gas pipe at the rear end of the circulating water cooling jacket, and the thermal spray nozzle at the tail end o...

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Abstract

The invention discloses a micro-fluidic chip-based capillary electrophoresis and graphite furnace atomic absorption online coupling interface device, which comprises an external capillary connected with a separation channel outlet of a micro-fluidic chip, wherein the other end of the eternal capillary is inserted into a thermo-spray tube; an air carrying tube and a circulating water cooling sleeve are sequentially sleeved outside the thermo-spray tube; a spray nozzle of the thermo-spray tube is horizontally inserted into a hollow graphite cap fixed in front of a graphite tube feeding hole; and the thermo-spray tube, the air carrying tube and the circulating water cooling sleeve are metal conductive bodies and are connected with the cathode of a power supply of the micro-fluidic chip so as to form a stable electric circuit for chip electrophoresis separation. In the interface device, through the design of a flow path of a tube-in-tube type sleeve flow at an interface, a separated species to be tested is vaporized and is continuously and stably introduced into a graphite tube at a constant speed in a thermo-spray way, which ensures the timely delivery of the species in a separated state. The interface simultaneously meets the detection requirements of micro-fluidic chip-based capillary electrophoresis separation and graphite furnace atomic absorption spectroscopy.

Description

【Technical field】: [0001] The invention belongs to the technical field of combined use of analytical chemical instruments, in particular to a new technology for online combined use of microfluidic chip capillary electrophoresis and graphite furnace atomic absorption spectrometry. 【Background technique】: [0002] The chemical form information of trace (trace) elements plays a very important role in the research fields of environmental science, biomedicine, food science, nutrition, trace element medicine, and new standards for the limit of toxic elements in commodities. The speciation analysis process generally includes chromatographic separation and atomic light (mass) spectrometry detection. Due to the complexity of the matrix and the trace amount of pollutants in biological and environmental samples, the combination of high-efficiency separation technology and high-sensitivity element selective detection technology is an important way to solve the analysis of trace element ...

Claims

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Application Information

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IPC IPC(8): G01N27/447G01N21/31
Inventor 李妍江焱严秀平
Owner NANKAI UNIV
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