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1'-acetoxyl chavicol acetate naonparticle

A technology of acetoxypiperol acetate and nanoparticles, which can be used in medical preparations of non-active ingredients, digestive system, organic active ingredients, etc., and can solve problems such as not meeting the requirements of preparations

Inactive Publication Date: 2010-09-29
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method was used to prepare solid dispersions with a mass ratio of ACA to polyethylene glycol 6000 of 1:5, 1:10, 1:15, and 1:20, and their solubility was 1.9, 1.4, 1.4, and 1.8 times that of ACA, respectively. , can not meet the requirements of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 1 part by weight of ACA and add it to water to dissolve it to make an ACA solution; take another 1 to 20 parts by weight of hydroxypropyl beta cyclodextrin and add it to water to dissolve it to make a clathrate material solution; under stirring, make the ACA solution Add it into the clathrate material solution to make an ACA clathrate solution, evaporate the solvent to dryness, pass through an 80-mesh sieve, and dry to make ACA nanoparticles.

[0034] Using known techniques, ACA nanoparticles can be made into injection or non-injection dosage forms, such as injections, oral dosage forms, powder sprays, sprays, aerosol dosage forms for external use, and the like.

Embodiment 2

[0036]Add 1 part by weight of ACA to 50% ethanol solution to dissolve to make ACA solution; take another 1 to 20 parts by weight of hydroxypropyl beta-cyclodextrin and add to 50% ethanol solution to dissolve to make clathrate material solution ; Under stirring, add the ACA solution to the clathrate material solution to make an ACA clathrate solution, evaporate the solvent to dryness, pass through a 80-mesh sieve, and dry to make ACA nanoparticles.

[0037] Using known techniques, ACA nanoparticles can be made into injection or non-injection dosage forms, such as injections, oral dosage forms, powder sprays, sprays, aerosol dosage forms for external use, and the like.

Embodiment 3

[0039] Take 1 part by weight of ACA and add it to absolute ethanol to dissolve it to make an ACA solution; take another 1 to 20 parts by weight of hydroxypropyl beta cyclodextrin and add it to absolute ethanol to dissolve it to make a clathrate material solution; Under stirring, add the ACA solution into the clathrate material solution to prepare an ACA clathrate solution, evaporate the solvent to dryness, pass through an 80-mesh sieve, and dry to prepare ACA nanoparticles.

[0040] Using known techniques, ACA nanoparticles can be made into injection or non-injection dosage forms, such as injections, oral dosage forms, powder sprays, sprays, aerosol dosage forms for external use, and the like.

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PUM

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Abstract

The invention discloses a 1'-acetoxyl chavicol acetate naonparticle consisting of 1 part by weight of 1'-acetoxyl chavicol acetate, 1-20 parts by weight of inclusion material and 0-1 part by weight of stabilizing agent and a preparation method thereof. Compared with a stake dispersion technology, the naonparticle has remarkable solubilizing effect which can reach over 200 times of the solubility of the 1'-acetoxyl chavicol acetate and has stable quality; compared with the 1'-acetoxyl chavicol acetate, the effect for resisting HIV (Human Immunodeficiency Virus) effect and the acute toxicity test result of the nanoparticle have no remarkable changes, no remarkable acrimony, sensitivity and hemolytic reactions. By adopting the known art, the nanoparticle is prepared into forms by an injected administration route or non-injected administration route.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, more specifically, to 1'-acetoxypiperol acetate nanoparticles and a preparation method thereof. Background technique [0002] The English name of 1’-acetoxychavicol acetate (ACA) is 1’-acetoxychavicol acetate (ACA), and the molecular formula is C 13 h 14 o 4 , the molecular weight is 234.25, and the structural formula is [0003] Chinese patent ZL031308767 reports that 1'-acetoxypiperol acetate, isolated and purified from the dry rhizome of Alpinia galanga Willd., a plant of the genus Zingiberaceae, has the ability to inhibit HIV-1 NL43 in MT-4 cells It has no effect on the survival of MT-4 cells. It shows high safety and the characteristics of inhibiting the extranuclear migration of HIV Rev protein. As a Rev protein inhibitor, it has significant anti-HIV-1 infection activity. [0004] There are also research reports showing that 1'-acetoxypiperol acetate has antitumor pr...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/48A61K31/222A61P1/02A61P17/02A61P31/06A61P31/10A61P31/18A61P35/00A61P39/06A61K47/61
Inventor 高永良朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG