Chlorphenesin carbamate and preparation method thereof

Abstract

The invention discloses chlorphenesin carbamate and a preparation method thereof. The preparation method comprises the step of mixing a compound shown in a formula (1) with ammonium reagent and alkali in an organic solvent in the presence of water at the temperature of 0-40 DEG C. The preparation method in the invention utilizes a raw material containing ammonium ions so as to avoid using of strong pungent ammonia water, improves production safety and is favor of environment protection.

Description

technical field The present invention relates to chlorophenyl glyceryl carbamate and preparation method thereof. Background technique Chlorphenesin Carbamate, as a muscle relaxant, has high curative effect and few side effects. At present, the synthesis route of chlorphenesin carbamate is mainly to react chlorphenesin ether with diethyl carbonate to generate a cyclic ether, which is further reacted with ammonia water to prepare chlorphenesin carbamate. Chinese patent application CN10162435 discloses a preparation method of chlorphenesin urethane, specifically, chlorphenesin reacts with diethyl carbonate under the action of a small amount of transesterification catalyst, and then adds tert-butanol, dimethylformamide and ammonia water, Chlorphenglyceryl carbamate. Owing to use ammoniacal liquor in above-mentioned synthetic route, and ammoniacal liquor is volatile, has strong irritant, has irritant to respiratory tract and skin, and damages central nervous system. If ammon...

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Problems solved by technology

Therefore, the production safety of the above-mentioned method is low

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