Preparation method and application of 2-substituted phenyl-2-(4,5,6,7-thiophane [3,2-c] pyridine-5(4H)-group) acetic acid (substituted alkyl alcohol) ester

Abstract

The invention belongs to the technical field of gastric ulcer resistant medicaments and provides 2-substituted phenyl-2-(4,5,6,7-thiophane [3,2-c] pyridine-5(4H)-group) acetic acid (substituted alkyl alcohol) ester with a structure of a formula I and a salt thereof, wherein R1 and R2 are simultaneously or respectively hydrogen, halogen or a nitro group; and R3 is a halogen substituted C1-C4 alkyl group or a hydroxyl group substituted C1-C4 alkyl group. The invention also relates to a preparation method of the compound, and also discloses a medical composition using the compound or the pharmaceutically acceptable salt thereof as an active and effective component and application thereof as gastric ulcer resistant medicaments.

Description

technical field The invention belongs to the technical field of medicine, more specifically, relates to a class of compounds with anti-gastric ulcer effect, their preparation method, pharmaceutical composition containing them and their use as anti-gastric ulcer drugs. Background technique Peptic ulcer is a common clinical disease and frequently-occurring disease, which has the characteristics of chronic course, periodic attacks, and rhythmic epigastric pain. At present, it is believed that its cause is due to the destruction of the balance of gastric and duodenal local mucosal protection factors and mucosal damage factors. Its protective factors mainly include mucus-mucosal barrier, mucosal blood flow and epithelial cell renewal, prostaglandins and epidermal growth factor, etc.; its damaging factors include gastric acid-pepsin digestion, gastric Helicobacter pylori, gastrin and gastric antrum Retention, poor diet and insomnia, alcohol consumption, emotional stress, adverse ...

AI Technical Summary

Problems solved by technology

At present, in view of the fact that proton pump inhibitors are more effective in inhibiting gastric acid than H 2 Beta-blockers are strong and therefore reduce the natural gastric acid barrier, leading to the growth of pathogenic bacteria in the gut

Although there are many drugs for the treatment of peptic ulcer, the treatment options are also diversified, and the short-term curative effect is relatively satisfactory, but recurrence is inevitable after drug withdrawal, and there are many adverse reactions after long-term medication, so new drugs of this type are needed

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