Sheep aphthovirus Asial type multi-epitope recombinant vaccine and preparation method thereof
A foot-and-mouth disease virus and recombinant vaccine technology, applied to sheep foot-and-mouth disease virus Asia1 type multi-epitope recombinant vaccine and preparation thereof, in the field of animal recombinant vaccine, can solve the problem of short duration, inability to meet epidemic prevention and control, and inability to protect against virus and other problems to achieve the effect of protecting against venomous attacks
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[0022] The preparation of embodiment 1 sheep foot-and-mouth disease virus Asia1 type multi-epitope recombinant vaccine
[0023](1) Design and synthesis of multi-epitope genes for foot-and-mouth disease: The whole genome sequence of Asia1 type foot-and-mouth disease virus JS / 05 strain (GenBank accession number: EF149009.1) was selected for multi-epitope design, that is, the main structural protein gene VP1 was selected. Two immunogenic B cell epitopes (136-160aa, 198-211aa) are properly connected in series, that is, 136-160aa-linker-198-211aa. The linker GGSSGG was added between the sites to minimize the impact between adjacent epitopes to ensure the integrity of the structure and function of the epitopes. To increase the potency of the epitope, the concatemer of the two epitopes was repeated once, ie: 136-160aa-linker-198-211aa-linker-136-160aa-linker-198-211aa. In order to insert the multi-epitope fusion gene into the recombinant expression vector, restriction sites were int...
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