Living body fluorescent endoscopic spectrum imaging device

Abstract

The invention relates to a live body fluorescent endoscopic spectrum imaging device, comprising a light source unit, a light split unit, a scanning light guide unit, a fiber bundle endoscopic unit, an electrooptical signal detection and acquisition unit and a computer, wherein the light source unit consists of a collimating unit and a band filter. The imaging device is characterized in that the light of the collimating unit passes through the band filter and then enters the light split unit, the light split unit is provided with two paths of interfaces, one path of the interfaces of the light split unit is connected with the scanning light guide unit, the scanning light guide unit is connected with the fiber bundle endoscopic unit, and the other path of the interfaces of the light split unit is connected with the electrooptical signal detection and acquisition unit which is connected with the computer. The imaging device has the characteristics that: 1, a Fourier transform spectrometer is used to detect a sample excitation spectrum, and has the advantages of high spectral resolution (1nm), adjustable spectral resolution and the like; and 2, the fluorescent live body endoscopic spectrum imaging system can provide not only imaging diagnosis at tissue level but also spectrum diagnosis at molecular level.

Description

technical field [0001] The invention belongs to the technical field of optical imaging, in particular to a living body fluorescent endoscopic spectral imaging device. Background technique [0002] Optical microscopy technology can provide effective information from the molecular level to the cellular level to the tissue level for the research of modern medicine, and help people diagnose, understand, and study various complex diseases and their pathogenic mechanisms at different scales. Since various representations in living organisms are easily affected by complex factors such as the pH, humidity, and temperature of the surrounding environment, it is of great practical significance to vigorously develop in vivo observation methods. Compared with in vitro observation, the data obtained by in vivo observation can more truly reflect the actual nature and state of the observed target, and the detection results are more accurate. In vivo fluorescence endoscopic imaging technolo...

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Problems solved by technology

Although this method is compatible with CCD detection, the spectral resolution is low due to the use of prisms, with an average of 6nm, which is not conducive to distinguishing different substances with similar emission spectra.

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