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Medical composite containing pirfenidone and preparation method thereof

The technology of a kind of pirfenidone and composition is applied in the field of pirfenidone medicinal composition, which can solve the problems that pirfenidone has not been listed on the market, etc., so as to achieve the effect of drug effect, fast dissolution rate, and reduce the discomfort of human body. Tolerance effect

Active Publication Date: 2010-12-15
BEIJING KAWIN TECH SHARE HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no pirfenidone on the market in China

Method used

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  • Medical composite containing pirfenidone and preparation method thereof
  • Medical composite containing pirfenidone and preparation method thereof
  • Medical composite containing pirfenidone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: preparation of pirfenidone tablet (0.2g / sheet)

[0026] Prescription: Pirfenidone 200g

[0027] Microcrystalline Cellulose 56g

[0028] Sodium carboxymethyl starch 20g

[0029] Hypromellose 6g

[0030] Magnesium Stearate 3g

[0031]

[0032] 1000 pieces

[0033] Take by weighing 20g sodium carboxymethyl starch and the pirfenidone and microcrystalline cellulose of prescription quantity and pulverize respectively, cross 80 mesh sieves respectively for subsequent use; The raw and auxiliary materials that will pulverize are taken by prescription quantity and mix evenly standby; Make soft material, granulate with 20 mesh sieve, dry at 50-60°C; pass through 20 mesh sieve for granulation, add prescription amount of magnesium stearate, and finally mix; measure the content of intermediates, determine the weight of the tablet, and compress the tablet; The plain tablet is coated (the we...

Embodiment 2

[0034] Embodiment 2: preparation of pirfenidone tablet (0.2g / sheet)

[0035] Prescription: Pirfenidone 200g

[0036] Microcrystalline Cellulose 56g

[0037] Sodium carboxymethyl starch 10g+10g

[0038] Hypromellose 6g

[0039] Magnesium Stearate 3g

[0040]

[0041] 1000 pieces

[0042] Weigh 10g of sodium carboxymethyl starch and place it at 105°C for drying for 5 hours for later use; weigh 10g of sodium carboxymethyl starch and the prescribed amount of pirfenidone and microcrystalline cellulose and pulverize them respectively, and pass through 80 mesh sieves respectively for later use; The raw and auxiliary materials are weighed according to the prescription amount and mixed evenly for later use; add distilled water to make the material into soft material, granulate with a 20-mesh sieve, and dry at 50-60°C; Sodium carboxymethyl starch, final mixing; measure the content of interme...

Embodiment 3

[0043] Embodiment 3: preparation of pirfenidone tablet (0.4g / sheet)

[0044] Prescription: Pirfenidone 400g

[0045] Microcrystalline Cellulose 112g

[0046] Sodium Carboxymethyl Starch 20g+20g

[0047] Hypromellose 12g

[0048] Magnesium Stearate 6g

[0049]

[0050]1000 pieces

[0051] Weigh 20g of sodium carboxymethyl starch and place it at 105°C for drying for 5 hours for later use; weigh 20g of sodium carboxymethyl starch and the prescribed amount of pirfenidone and lactose and pulverize them respectively, and pass through 80 mesh sieves respectively for later use; the crushed raw and auxiliary materials Weigh and mix evenly according to the prescription amount for later use; add distilled water to make the material soft material, granulate with a 20-mesh sieve, and dry at 50-60°C; pass through a 20-mesh sieve for granulation, add the prescription amount of magnesium stearate and 20g carboxymethyl Sodium sta...

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Abstract

The invention provides a medical composite containing pirfenidone, which is characterized by containing 20-90% of pirfenidone, 10-50% of filler, 1-10% of disintegrating agent, 0.1-8% of adhesive and 0.2-3% of lubricant.

Description

[0001] The invention relates to a pirfenidone medicinal composition and a preparation method of the composition. technical background: [0002] Idiopathic pulmonary fibrosis (IP F) is a common disease all over the world, and its morbidity and mortality have increased in the past 10 years. It is estimated that the number of patients suffering from IPF in the United States, Europe and Japan is about 220,000 , of which there are 90,000 IPF patients in the United States. IPF is comparable in prevalence to diseases such as chronic myelogenous leukemia (CML). The disease is a progressive disease. The development of secondary pulmonary fibrosis is relatively slow, and the development of pulmonary fibrosis can stop after removal of the cause caused by external causes. Pulmonary fibrosis is a disease of the respiratory system. In addition to the fibrosis of interstitial diseases of the lung itself, pulmonary fibrosis can be formed due to damage to the lung interstitium by diseases of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61K47/38A61P11/00
Inventor 杨成
Owner BEIJING KAWIN TECH SHARE HLDG
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