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Method and instrument of ultrasonic and electric field superposition target medicine penetration

A technology of ultrasound and electric field, which is applied in the field of superimposed ultrasound and electric field target drug penetration, which can solve the problems of tissue damage, dosage and site restrictions of drug administration, and achieve the effect of improving the effect and painless action process

Inactive Publication Date: 2010-12-22
翁春晓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high-pressure impact on human tissues in this type of method, it can cause tissue damage and pain, so the dosage and site of administration are strictly limited, and it has not been widely used in clinical practice so far.

Method used

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  • Method and instrument of ultrasonic and electric field superposition target medicine penetration
  • Method and instrument of ultrasonic and electric field superposition target medicine penetration
  • Method and instrument of ultrasonic and electric field superposition target medicine penetration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Parameter scheme:

[0021] Ultrasonic frequency: 20KHz,

[0022] Ultrasonic power: 200mW / cm 2 ,

[0023] Ultrasonic output form: pulsating, period 20ms, duty ratio 1:1,

[0024] Electroporation: square wave, duty ratio 1:1, period 30ms,

[0025] Pore ​​forming voltage: 100V

[0026] Ion introduction waveform: 2000Hz square wave, duty ratio 1:1,

[0027] Modulation waveform: 100Hz sine half wave,

[0028] Peak voltage: 30V

[0029] Output time: 30min

[0030] Output program: 10s electroporation pilot pulse and subsequent ultrasonic conductance superimposed output repeated every 10min.

[0031] The structure process of the instrument is:

[0032] The network power input cable is connected to the power socket fixed on the rear panel of the instrument shell, the fuse is connected between the power socket and the primary input line of the transformer fixed on the bottom plate of the shell, and the bridge rectifier circuit of the main circuit board is connected to th...

Embodiment 2

[0033] Example 2: In vivo test, using the instrument obtained in Example 1, to conduct ultrasound conductance drug penetration and tissue drug concentration determination in rabbits.

[0034] Take a healthy rabbit with a body weight of 2.0±0.5kg, fix the hairless skin on the buttocks and paste a hollow patch, add 5% ketoprofen gel to the hollow area, immerse the treatment head in the gel, and apply a 100V pore-forming pulse 5 One, 20KHz ultrasonic wave and 30V conductance pulse for 10min, after the end, the rabbit was killed quickly, the tissue of the administration site was taken and ground to extract the interstitial fluid containing ketoprofen, the components were recovered, and detected by high performance liquid phase.

[0035] Rabbits in the control group were orally administered with the same dose of ketoprofen, and sacrificed 10 minutes later. Others are the same as the experimental group.

[0036] Liquid phase conditions:

[0037] Mobile phase: KH 2 PO 4 (0.07M, pH4...

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Abstract

Method and instrument of ultrasonic and electric field superposition target medicine penetration are disclosed. The method comprises the steps of outputting physical energy ultrasonic and electric field in a certain form in programming and superposing way which can promote medicines to penetrate into an organism through skin; organically and jointly applying to a medicines in a certain medicine form so that the ultrasonic, the electropration and iontophoresis can jointly promote the medicines to penetrate into the organism by respective characteristics to form a certain medicine concentration in partial tissues to realize partial treatment by target medicine penetration. The instrument comprises a host and an application part, wherein the host comprises a power supply part, a signal generating and processing part, an adjusting control and display part and the like; the application part comprises an interconnecting plug, an output cable and a treatment head; the power supply part mainly comprises a net power supply connecting line, a fuse protector, a voltage-transformation and rectifying device and the like; the signal generating and processing part comprises a signal generating circuit, a signal amplifying circuit and a signal modulator circuit; the control and display part mainly comprises a parameter setting circuit, a parameter display circuit and a parameter display device; the treatment head comprises a shell, a transmission electrode; a ultrasonic transducer and the like; the power supply part inputs the current of the net power supply into the signal generating and processing part; electric signals of a driving ultrasonic transducer and a medicine penetration electric field are generated, amplified and modulated by the signal generating and processing part; the control and display part realizes the setting, the adjustment and the display of output signal parameters; the application part transmits the electric signals to the treatment head.

Description

Technical field: [0001] The invention relates to a method and an instrument for superimposing ultrasonic waves and an electric field to penetrate drugs at target positions, and belongs to the field of instruments for injecting media into human bodies. Background technique: [0002] Among the many methods of administration, oral administration and injection are still the most important routes of administration. Their common feature is that after the drug enters the human body through different channels, it will form a certain drug concentration in the blood, and then distribute to various tissues of the whole body along with the circulation, forming a certain tissue concentration. Drugs distributed in diseased tissues play a therapeutic role, while drugs distributed in normal tissues often cause toxic side effects. [0003] In oral and injection administration, in order to improve the curative effect of the drug and the duration of the drug effect, it is usually necessary to...

Claims

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Application Information

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IPC IPC(8): A61M37/00
Inventor 翁春晓
Owner 翁春晓