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Mu-sarin nanogel

A nano-gel and banana peelin technology, which is applied in skin diseases, capsule delivery, microcapsules, etc., can solve the problems of clinical application limitations and achieve the effects of high drug loading, high stability, and reduced penetration

Inactive Publication Date: 2018-03-23
CHENGDU SHENGERJIA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the limited drug loading and relative stability of these drugs limit their clinical application.

Method used

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  • Mu-sarin nanogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment provides a banana peelin nanogel, which has a core-shell structure and high stability. At the same time, its drug loading is high, which can significantly increase the retention of the drug on the skin and reduce the permeation of the drug through the skin. , so as to prolong the action time of the drug and meet the requirements of local treatment.

[0034] The banana peelin nanogel provided in this embodiment comprises 0.5% banana peelin by mass, polylactic acid-glycolic acid copolymer 3.2%, polyamide-amine 11.4%, polyvinyl alcohol 7.0%, polyoxyethylene dehydration Sorbitol monolaurate 0.8%, sodium triphosphate 0.01%, menthol 0.2%, carbomer 25%, and the balance is water.

[0035] The banana peelin nanogel provided by the present embodiment is prepared through the following steps:

[0036] Step 1: dissolving banana peelin in ethanol, dissolving polylactic acid-glycolic acid copolymer in chloroform, after completely dissolving, fully mixing the two to ob...

Embodiment 2

[0042] This embodiment provides a banana peelin nanogel, which has a core-shell structure and high stability. At the same time, its drug loading is high, which can significantly increase the retention of the drug on the skin and reduce the permeation of the drug through the skin. , so as to prolong the action time of the drug and meet the requirements of local treatment.

[0043] The banana peelin nanogel that present embodiment provides comprises the banana peelin 0.8% by mass, polylactic acid-glycolic acid copolymer 3.4%, polyamide-amine 11.8%, polyvinyl alcohol 7.4%, Tween 60 1% , sodium triphosphate 0.02%, borneol 0.3%, hypromellose 25%, and the balance is water.

[0044] The banana peelin nanogel provided by the present embodiment is prepared through the following steps:

[0045] Step 1: dissolving banana peelin in ethanol, dissolving polylactic acid-glycolic acid copolymer in acetone, after completely dissolving, fully mixing the two to obtain an organic phase.

[0046...

Embodiment 3

[0051] This embodiment provides a banana peelin nanogel, which has a core-shell structure and high stability. At the same time, its drug loading is high, which can significantly increase the retention of the drug on the skin and reduce the permeation of the drug through the skin. , so as to prolong the action time of the drug and meet the requirements of local treatment.

[0052]The banana peelin nanogel provided by the present embodiment comprises 2% banana peelin by mass, polylactic acid-glycolic acid copolymer 3.8%, polyamide-amine 12.6%, polyvinyl alcohol 8.2%, polyoxyethylene mono-oil Ester 1.5%, sodium triphosphate 0.01%, menthol 0.4%, carbomer 35%, and the balance is water.

[0053] The banana peelin nanogel provided by the present embodiment is prepared through the following steps:

[0054] Step 1: dissolving banana peelin in ethanol, dissolving polylactic acid-glycolic acid copolymer in ethyl acetate, after completely dissolving, fully mixing the two to obtain an org...

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Abstract

The invention discloses a banana peel nano gel, which relates to the field of pharmaceutical preparations. The raw material of banana peelin nanogel provided by the present invention comprises banana peelin 0.5-2%, polylactic acid-glycolic acid copolymer 3.2-3.8%, polyamide-amine 11.4-12.6%, polyvinyl alcohol 7.0-8.2%, Emulsifier 0.8-1.5%, sodium triphosphate 0.01-0.02%, skin penetration enhancer 0.2-0.4%, gel base 25-35%, and the balance is water. The banana peelin nanogel provided by the invention has a core-shell structure and high stability. As a new type of drug, banana peelin nanogel has a high drug loading capacity, which can significantly increase the skin retention of the drug and reduce the percutaneous penetration of the drug, thereby prolonging the action time of the drug and meeting the requirements of local treatment. It is a new type of drug. A new dosage form for topical application, and provides a basis for the wide application of scabalenin.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a banana peel nanogel. Background technique [0002] Banana peel is a natural substance that widely exists in fruits and peels, and its content is particularly high in banana peels. Studies have proved that banana peelin can be used to treat high blood pressure and prevent cerebral hemorrhage; especially in the field of skin disease treatment, it has a wide application prospect: preventing and treating chapped and frostbite; resisting skin pruritus caused by fungal and bacterial infections, and anti-inflammatory and pain-relieving. However, due to the poor skin permeability of succumin, its clinical application is limited, so in the prior art, there are relatively few preparations related to succumin. [0003] In recent years, the development of new drug delivery systems, especially those based on nanocarriers, has provided more options and opportunities for the treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/88A61K47/34A61K47/32A61K47/10A61K47/02A61K9/51A61P9/12A61P9/10A61P7/04A61P17/02A61P31/10A61P31/04A61P31/02A61P17/04A61P29/00
CPCA61K9/06A61K9/0014A61K9/5138A61K9/5146A61K9/5153A61K36/88A61K47/02A61K47/10
Inventor 卢晔
Owner CHENGDU SHENGERJIA SCI & TECH