Combined medicament of omeprazole sodium

A technology of omeprazole sodium and medicine, applied in the directions of medicine combination, medicine formula, non-active ingredient medical preparations, etc., can solve problems such as adverse reaction liver, allergic reaction, damage reaction, etc., so as to reduce liver damage and avoid Allergic reaction, the effect of improving inner quality

Inactive Publication Date: 2011-01-19
吴赣英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the existing omeprazole sodium preparations that are prone to cause allergic reactions, adverse reactions, and liver damage reactions after taking the existing omeprazole sodium preparations, the invention provides a combination drug of omeprazole sodium

Method used

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  • Combined medicament of omeprazole sodium
  • Combined medicament of omeprazole sodium
  • Combined medicament of omeprazole sodium

Examples

Experimental program
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Effect test

Embodiment 1

[0027] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0028] Omeprazole sodium: 17.3

[0029] Reduced Glutathione 8.7

[0030] Sodium glutamate 43.5

[0031] The preparation method of above-mentioned combination medicine is as follows:

[0032] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0033] (2). The solution obtained by the membrane ultrafiltration step (1) with a molecular weight cut-off of 8000D, the filtrate is ultrafiltered by a membrane with a molecular weight cut-off of 1500D, and the filtrate is adjusted to a pH value of 7.2 to 7.6 with 8% sodium hydroxide solution.

[0034] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C. for 20 minu...

Embodiment 2

[0052] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0053] Omeprazole sodium: 34.8

[0054] Reduced Glutathione 13.0

[0055] Sodium glutamate 52.2

[0056] The preparation method of above-mentioned omeprazole sodium combination medicine is:

[0057] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0058](2). Be the solution that the membrane ultrafiltration step (1) that molecular weight cut off is 8000D obtains, and filtrate is the membrane ultrafiltration of 1500D with molecular weight cut off, and filtrate is regulated pH value to 7.2~7.6 with 8% sodium hydroxide solution.

[0059] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C. for 20 minutes...

Embodiment 3

[0077] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0078] Omeprazole sodium: 29.1

[0079] Reduced Glutathione 10.2

[0080] Sodium glutamate 46.3

[0081] The preparation method of above-mentioned omeprazole sodium combination medicine is:

[0082] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0083] (2). The solution obtained by the membrane ultrafiltration step (1) with a molecular weight cut-off of 8000D, the filtrate is ultrafiltered by a membrane with a molecular weight cut-off of 1500D, and the filtrate is adjusted to a pH value of 7.2 to 7.6 with 8% sodium hydroxide solution.

[0084] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C. for...

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Abstract

The invention discloses a combined medicament of omeprazole sodium and a method for preparing the same. The combined medicament of omeprazole sodium comprises the following medicinal ingredients in part by weight: 17.3 to 34.8 parts of omeprazole sodium, 8.7 to 13.0 parts of reduced glutathione and 43.5 to 52.2 parts of sodium glutamate. The combined medicament of omeprazole sodium provided by the invention has an effect of resisting medicament allergy, can relieve the effect and the adverse reaction of the meprazole sodium on damage to liver and has high medicament quality; and the preparation method has the advantages of energy conservation and environmental protection.

Description

[0001] This application is an application for enjoying the priority of the prior patent in China. The application number of the prior patent is 2010100004907, the application date is January 11, 2010, and the name is a combination drug of omeprazole sodium and its preparation method. technical field [0002] The invention relates to a combination medicine of omeprazole sodium and a preparation process thereof. Background technique [0003] The gastric and duodenal mucosa has a natural and perfect mechanism to resist the erosion of gastric acid and pepsin, but when it is damaged by Helicobacter pylori and non-steroidal anti-inflammatory drugs, peptic ulcer disease will occur. Australian scholars Warren and Marshall reveal the etiology, and have H 2 Receptor antagonist therapy drugs are effective in treatment, and 22 years later, the two were awarded the 2005 Nobel Prize in Medicine. In the 1980s, there were proton pump inhibitor drugs for the treatment of peptic ulcer disea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K47/20A61K47/18A61P1/04
Inventor 蔡海德
Owner 吴赣英
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