Differentiation of human embryonic stem cells
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- LIFESCAN INC
- Publication Date
- 2011-01-19
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Abstract
Description
technical field
[0001] The present invention provides methods for promoting differentiation of pluripotent stem cells. In particular, the present invention provides improved methods for forming pancreatic endoderm, pancreatic hormone expressing cells, and pancreatic hormone secreting cells. The present invention also provides methods of promoting differentiation of pluripotent stem cells without the use of a feeder cell layer. Background technique
[0002] Advances in cell replacement therapy for type I diabetes and the scarcity of transplantable islets have focused attention on developing a source of insulin-producing cells or beta cells suitable for engraftment. One approach is to generate functional beta cells from pluripotent stem cells, such as embryonic stem cells.
[0003] In vertebrate embryonic development, pluripotent stem cells can give rise to a group of cells comprising the three germ layers (ectoderm, mesoderm and endoderm) in a process called gastrulation. ...