Antithrombin preparation and preparation method thereof

Abstract

The invention relates to an antithrombin enteric soft capsule preparation which is prepared by using part or all of leech, bloodsucker, whitmania acranulata Whitman, hirudinaria manillensis, dinobdella ferox, Haemadipsa japonica Whitman and Haemadipsa sylvestris as raw materials and other pharmaceutically acceptable auxiliary materials. The preparation method comprises the steps of: 1, preparing powder for preparation; 2, preparing contents in teh soft capsule; and 3, preparing the tenteric soft capsule. The preparation process for the enteric soft capsule preparation has the advantages of improving the stability, improving the transfer rate of effective components, lowering the production stroage requirements, reducing the process difficulty, and has the positive meanings on increasing the stability, quickening the development of the soft capsule preparations, improving the quality, and lowering the production cost.

Description

Technical field:

[0001] The invention relates to an antithrombin preparation, in particular to an enteric-coated soft capsule of a natural thrombin inhibitor and a preparation method thereof. Background technique:

[0002] Modern pharmacological studies have shown that hirudin can prevent the action of thrombin on fibrinogen and hinder blood coagulation. However, due to the poor stability of hirudin, the transfer rate of active ingredients in medicinal materials is not high, resulting in a great waste of medicinal materials; production conditions The requirement is higher, and the storage condition of the finished product is a shady and cool warehouse, which makes the production cost larger, and the storage after transportation and purchase becomes a big problem; with the development of modern medical technology, the blood-sucking animal leech (Whitmania pigra Whitman), Hirudo nipponica Whitman, Whitmania acranulata Whitman, Poecilobdella manillensis, Dinobdella ferox, Haema...

Images