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Compound composition containing nitrobrate

A technology of nitrofibrate and composition, which is applied in the field of medicine, can solve problems such as elevated transaminases, achieve the effect of small liver side effects and increase high-density lipoprotein

Inactive Publication Date: 2011-02-02
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, similar to other lipid-lowering drugs, fenofibrate often produces side effects of elevated transaminases in clinical application

Method used

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  • Compound composition containing nitrobrate
  • Compound composition containing nitrobrate
  • Compound composition containing nitrobrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] prescription:

[0011]

[0012] Process:

[0013] 1. Dissolve PEG 6000 and Poloxamer 188 at 70°C and mix.

[0014] 2. Dissolving or dispersing atorvastatin and nitrofibrate in the above mixed solution.

[0015] 3. In a molten state, spray the mixed solution obtained in step 2 into lactose powder to form drug-loaded granules.

[0016] 4. Add magnesium stearate to the drug-loaded granules obtained in step 3, and press into tablets to obtain the product, with a tablet weight of 700 mg.

Embodiment 2

[0018] prescription:

[0019]

[0020]

[0021] Process:

[0022] 1. Dissolve PEG 6000 and Poloxamer 188 at 70°C and mix.

[0023] 2. Dissolving or dispersing rosuvastatin and nitrofibrate in the above mixed solution.

[0024] 3. In a molten state, spray the mixed solution obtained in step 2 into lactose powder to form drug-loaded granules.

[0025] 4. Add magnesium stearate to the drug-loaded granules obtained in step 3, and press into tablets to obtain the product, with a tablet weight of 700 mg.

Embodiment 3

[0027] prescription:

[0028]

[0029] Process:

[0030] 1. Dissolve PEG 6000 and Poloxamer 188 at 70°C and mix.

[0031] 2. Dissolve or disperse fluvastatin and nitrofibrate in the above mixed solution.

[0032] 3. In a molten state, spray the mixed solution obtained in step 2 into lactose powder to form drug-loaded granules.

[0033] 4. Add magnesium stearate to the drug-loaded granules obtained in step 3, and press into tablets to obtain the product, with a tablet weight of 700 mg.

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PUM

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Abstract

The invention relates to a compound composition containing nitrobrate, which is formed by using the nitrobrate and an HMG-CoA reductase inhibitor as active components to be combined with pharmaceutically acceptable assistant materials. The composition can be prepared into oral preparations of granules, tablets, capsules, soft capsules, chewable tablets, orally disintegrating tablets, buccal tablets, pills and the like, and can be used for controlling and reducing the level of blood fat for long.

Description

technical field [0001] The invention relates to a compound composition containing nitrofibrate, which belongs to the technical field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one disease threatening human life and health. Hypercholesterolemia characterized by elevated levels of plasma low-density lipoprotein and very low-density lipoprotein is one of the main pathogenic factors of cardiovascular and cerebrovascular diseases; increased blood lipids can also lead to fatty liver and cirrhosis. Blood lipid lowering therapy has become an important means to prevent and treat coronary heart disease and other cardiovascular and cerebrovascular diseases, and it is also an effective measure to treat fatty liver, liver fibrosis and liver cirrhosis. [0003] Statins can significantly lower plasma cholesterol (CH) and low-density lipoprotein cholesterol (LDL-C). By inhibiting hydroxyglutaryl coenzyme A (HMG CoA) reductase, it ...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P3/06A61K45/00
Inventor 李宝齐王晓丹
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD