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Extraction method, extract and pharmaceutical use of hypericum perforatum extract

A technology of Hypericum perforatum and extract, applied in the field of medicine, can solve the problems of inability to apply large-scale production, inability to effectively prevent the oxidation of hypericin, poor effect and the like

Active Publication Date: 2011-03-16
威海世纪博康海藻有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method can obtain more hypericin, on the one hand, this application fails to effectively solve the stability problem of hypericin and hypericin; on the other hand, the resin column for adsorption contains various organic residues. Drugs are strictly restricted by the Food and Drug Administration in actual pharmacy, and cannot be applied to large-scale production in industry
Chinese patent 96197288 discloses a stabilizer suitable for the conventional extraction process of Hypericum perforatum: organic thiol compound and ascorbic acid, which can effectively prevent the oxidation of hypericin, but this scheme cannot effectively prevent the oxidation of hypericin Oxygenated and therefore less effective
[0007] Other technical solutions in the prior art, such as 200410017828, discloses the extraction method using ethanol+high performance liquid chromatography column; 201010165482 discloses the method of using catalytic enzyme extraction, such technical solutions are still unable to realize large-scale industrial production, and Also does not improve the stability of the extract and extraction process

Method used

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  • Extraction method, extract and pharmaceutical use of hypericum perforatum extract
  • Extraction method, extract and pharmaceutical use of hypericum perforatum extract
  • Extraction method, extract and pharmaceutical use of hypericum perforatum extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Get 1kg Hypericum perforatum, join 1%KOH and 8%NaHCO3 in the solution 3000ml, soak and 40 ℃ warm soak for 60 minutes, and the obtained filtrate residue is with 1.5% NaHCO Solution 1000ml40 ℃ warm soak for 60 minutes. Combine the obtained filtrates and concentrate under reduced pressure at 45°C to obtain the extract, add the obtained extract to 500ml of 80% ethanol solution, filter, concentrate the filtrate under reduced pressure to remove ethanol, repeat twice, add 1% of Sodium bisulfite, 1.5% methionine (by weight), dried to obtain 30 g of granular Hypericum perforatum extract, wherein the content of hypericin was 9.24%, and the content of hypericin was 2.31%.

Embodiment 2

[0025] Get 1000g Hypericum perforatum, squeeze it into 410ml of squeeze liquid with a squeeze machine, add 2% sodium metabisulfite and 3% thioglycerol therein, by mass, the gained squeeze liquid is mixed with the solid residue produced by squeezing, and then Added to 500ml 65% ethanol solution under dark conditions and stirred and dissolved for 50 minutes, the filtrate was concentrated to remove ethanol; repeated three times, the obtained concentrated solution was combined and dried, and the obtained dried extract was pulverized to obtain 39g of Hypericum perforatum extract. After determination, the hypericin content is 2.40%, and the hypericin content is 8.25%.

Embodiment 3

[0027] Get 1000g Hypericum perforatum, squeeze it into 410ml of squeeze liquid with a press, add 0.03% sodium metabisulfite, 0.02% sodium bisulfite, 0.4% methionine, 0.01% thioglycerol, According to the calculation method, the obtained squeezing liquid is mixed with the solid residue produced by squeezing, and then added to 800ml n-heptane solution under the condition of protecting from light and nitrogen, stirring and dissolving for 30 minutes, and the filtrate is concentrated to remove the solvent; repeat three times, and the obtained concentration The liquids were combined and dried, and the obtained dry extract was pulverized to obtain 21 g of Hypericum perforatum extract. After determination, the hypericin content is 1.63%, and the hypericin content is 27.8%.

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Abstract

The invention discloses a method for preparing a hypericum perforatum extract. By the preparation method, a stable composition of the hypericum perforatum extract can be prepared, particularly a hypericin and hyperforin-containing composition. In addition, the invention also discloses a stable composition of the hypericum perforatum extract and use thereof for preparation of medicaments.

Description

technical field [0001] The invention discloses a stable Hypericum perforatum extract composition and an extraction preparation method thereof, and further relates to a stable Hypericum perforatum extract and hypericin extract and an extraction preparation method, belonging to the field of medicines. Background technique [0002] Hypericum perforatum (also known as Hypericum perforatum), whose scientific name is Hypericum perforatumL, is a plant of the genus Hypericum in the family Garcinia. Existing pharmacological and clinical experiments have proved that the extract of Hypericum perforatum can be effectively used to treat depression and Anxiety-like psychiatric diseases have been used clinically in Germany to treat mild and moderate depression. Studies have confirmed that the main components of Hypericum perforatum extract are hypericin and hypericin. [0003] Hypericin has antiviral, antitumor, antidepressant and other pharmacological activities. Its molecular weight is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K47/02A61K47/20A61P25/22A61P25/24
Inventor 郝守祝
Owner 威海世纪博康海藻有限公司
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