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Glaucescent fissistigma root saponin composition and preparation method thereof

A technology of hibiscus and composition, applied in the field of composition of hibiscus saponin extract and its preparation, can solve problems such as poor clarity, achieve increased solubility and stability, significant anti-tumor, and ensure stability Effects of Sex and Safety

Inactive Publication Date: 2011-03-30
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The applicant found that there were problems in solubility and stability when preparing injections from the extract of Akia saponin, which was manifested in poor clarity during the preparation process and after high-temperature sterilization. In order to obtain a stable Akia saponin injection , the inventor has overcome the above problems and completed the present invention

Method used

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  • Glaucescent fissistigma root saponin composition and preparation method thereof
  • Glaucescent fissistigma root saponin composition and preparation method thereof
  • Glaucescent fissistigma root saponin composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 50kg of the medicinal material of Aegypti sinensis, crush and cut it into coarse powder, put it into a heat reflux extraction tank, add 8 times the amount of 75% ethanol, heat and reflux extraction 3 times, each time for 2h, release the extract, combine, filter, and concentrate the filtrate to 10L, add an equal volume of ethyl acetate to extract 3 times, combine the ethyl acetate solution, concentrate to a thick paste, then add 50L of ethyl acetate to dissolve, filter, pass the filtrate through a neutral alumina column, and add 50L of ethyl acetate Elution, TLC monitoring, collection of black bone saponin part, and concentrated to dryness, to obtain black bone saponin extract 1.5kg. The total saponins were determined by ultraviolet-visible spectrophotometry, and the content was 52%.

Embodiment 2

[0036] Take 50kg of Chinese herbal medicine, crush and cut into coarse powder, put it into a hot reflux extraction tank, add 7 times the amount of 95% ethanol, heat and reflux extraction 3 times, each time for 1.5h, release the extract, combine, filter, and concentrate the filtrate to 10L, add an equal volume of ethyl acetate to extract 4 times, combine the ethyl acetate solution, concentrate to a thick paste, then add 60L of ethyl acetate to heat to dissolve, filter, pass the filtrate through a neutral alumina column, and add 60L of ethyl acetate Esters were eluted, and TLC monitoring was performed to collect the black bone saponin part and concentrate to dryness to obtain 1.8 kg of black bone saponin (a).

[0037]Take the crude product (a), add 50L of water, stir to dissolve, filter the plate and frame, pass the filtrate through a chromatography column connected in series by polyamide (60-100 mesh, 20L)-macroporous resin (HPD-400, 50L), wash thoroughly with water After strip...

Embodiment 3

[0040] Take 100kg of the medicinal material of Aegypti sinensis, crush and cut into coarse powder, put it into a heat reflux extraction tank, add 8 times the amount of 75% ethanol, heat and reflux for extraction 3 times, each time for 2 hours, release the extract, combine, filter, and concentrate the filtrate to 20L, add an equal volume of ethyl acetate to extract 3 times, combine the ethyl acetate solution, concentrate to a thick paste, then add 50L ethyl acetate to dissolve, filter, pass the filtrate through a neutral alumina column, and add 50L ethyl acetate Elution, TLC monitoring, collection of black bone saponin part, and concentrated to dryness, to obtain black bone saponin crude product (a) 3.2kg.

[0041] Take the crude product (a), add 100L of water, stir to dissolve, filter the plate and frame, pass the filtrate through a chromatographic column connected in series by polyamide (100-200 mesh, 20L)-macroporous resin (HPD-100, 100L), and wash thoroughly with water. Aft...

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Abstract

The invention relates to a glaucescent fissistigma root saponin composition and a preparation method thereof, in particular to a composition containing a glaucescent fissistigma root saponin extract and hydroxyl propyl-beta-cyclodextrin.

Description

technical field [0001] The invention relates to a composition of acacia saponin extract and a preparation method thereof, belonging to the technical field of medicine, specifically to the field of pharmaceutical preparations. Background technique [0002] Black bone vine, also known as Tongguangsan, Tongguansan, Tongguang vine, Tongguan vine, is Marsdenia tenacissima (Roxb.) Wight et Arn. ) cane. Mainly produced in Yunnan, Guizhou and other places, it was first recorded in "Southern Yunnan Materia Medica". Black bone vine contains various chemical components such as steroidal ester glycosides, alkaloids, organic acids, polysaccharides, resins and pigments. It has a wide range of pharmacological activities, such as anti-tumor, immune regulation, liver protection and diuretic effects. With the deepening of the research on the chemical constituents of S. sinensis, the anti-tumor effect of saponins with C21 steroidal saponin core has been gradually clarified. [0003] At pre...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K47/40A61P35/00A61K135/00
Inventor 郭安军王衡奇石赟蓉董李娜张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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