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Haemostatic and wound dressing containing same

The technology of a hemostatic agent and polysaccharide is applied in the field of hemostatic agents and wound dressings containing the hemostatic agent, which can solve the problems of light flake particles, inconvenient use, unsatisfactory water absorption rate and absorption capacity of chitosan, etc. The effect of strong adhesion, accelerated formation, good water solubility and biocompatibility

Inactive Publication Date: 2011-04-13
常云峰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

us army option Chitosan blocks and chitosan tablets were produced as a hemostatic agent, but due to its inconvenient use, WoundStat was used instead TM
Celox TM A sheet-like blood control agent mainly composed of chitosan has been produced. The chitosan is in the form of granules. Requirements for use as a hemostatic agent

Method used

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  • Haemostatic and wound dressing containing same
  • Haemostatic and wound dressing containing same
  • Haemostatic and wound dressing containing same

Examples

Experimental program
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Effect test

preparation example Construction

[0041] Wherein N, O-carboxymethyl chitosan (CMC) preparation method, step is as follows:

[0042] (1) dissolving: the commercially available chitosan of 40.0g (viscosity is 1080cPs, contains 1% chitosan solution with 1% acetic acid solution configuration, adopts Brooksield rotor viscometer, No. 4 rotor, records under 5rpm. Room temperature Mix with 695ml of isopropanol;

[0043] (2) Synthesis: 131.5 g of 10.16 M aqueous sodium hydroxide solution was gradually added to the above-mentioned slurry (isopropanol solution) within 20 minutes, and then stirred for 1 hour; under stirring, 48.0 g of monochloroacetic acid Add the above mixed solution within 20 minutes, then heat the temperature of the mixture to 60° C. and maintain the temperature for 3 hours; then, cool the mixed solution, filter and separate to obtain a solid product;

[0044] (3) Washing: resuspend the solid obtained in step (2) in 1 liter of 70% (v / v) methanol-water solution, place it for 15 minutes, add 3 ml of gla...

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PUM

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Abstract

The invention relates to a haemostatic and wound dressing containing the same. The haemostatic is a single polysaccharide or single hydrogel particle, or is prepared by combining at least one polysaccharide onto the surface of a hydrogel particle in a physical or chemical combining way by virtue of polymerization reaction or grafting reaction, or mixing the hydrogel particle with a polysaccharideparticle; and the wound dressing contains the haemostatic. The haemostatic prepared by the invention can effectively stop hemorrhea threatening life in wound, haemostasis can be realized by adhering,pressing or applying the haemostatic onto a wounded part, formation of a blood plaque at the wounded part can be sped up, and meanwhile formation of a blood clot at the wounded part can be sped up, thus preventing blood drain at the wounded part and preventing blood outflow at the wounded part.

Description

technical field [0001] The invention belongs to the field of trauma hemostasis, and relates to a hemostatic agent and a preparation method thereof, in particular to a hemostatic agent and a wound dressing containing the hemostatic agent. Background technique [0002] Excessive hemorrhage is the main cause of death from trauma on the battlefield, and the death caused by excessive hemorrhage accounts for about 50% of traumatic deaths, especially in remote areas or in other extreme situations, the wounded cannot immediately Serious trauma can worsen without medical attention, so it is important to stop bleeding in time to allow the injured person or animal enough time to receive medical treatment. According to statistics, one-third of the deaths caused by excessive bleeding can be avoided by improving the methods and devices of bleeding control. Improved techniques and methods of hemostasis are also very useful in other non-military settings, such as in hospitals, veterinary c...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/24A61L15/28
Inventor 常云峰杨芳晓周泽奇
Owner 常云峰
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