Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof
A micro-device, non-invasive technology, applied in separation methods, biochemical equipment and methods, separation of microorganisms, etc., can solve problems such as limiting the ultrasonic action area and processing volume channel measurement accuracy limitations
Inactive Publication Date: 2011-04-20
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) +2
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Problems solved by technology
This device is closest to the device of the present invention, but their significant difference is that it can cause certain operational limitations (as the case may be), such as the inability to apply continuous waves and physically limit the active area (this is caused by the two ultrasonic emission sources). The constrained space between and the geometrically symmetrical layout of the inflow and outflow channels relative to the central processing channel is determined), thereby strongly limiting the ultrasonic active area
Contrary to the present invention, this λ / 4 device operates at about f=4 MHz and is accurate for the processing volume (whose cross-section is inversely proportional to frequency (about 4 times smaller than the present invention)) and the channels required for the aforementioned reasons Significant restrictions on sexuality
Method used
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[0110] specific implementation plan
[0111] The first embodiment describes a first prototype of the microdevice of the invention.
[0112] exist Figure 4 In the prototype shown, the structural material used to realize the fluidic channels was the photodefinable polymer SU-8 mechanically bonded to a PMMA substrate that constituted the channel bottom of the device. Due to its high confinement (micrometer scale), verticality of the grown walls [ref2], biocompatibility [ref3], wide thickness range [ref1] and possibility of gluing several successive layers [ref4], the material Very convenient feature for manufacturing devices. according to figure 1 The design of this prototype of the device of the present invention used is manufactured as follows (see Figure 10 ):
[0113] a) depositing and defining a photodefinable polymer layer on the surface of a free-standing substrate (wafer 1),
[0114] b) depositing and defining a photodefinable polymer SU-8 layer on the surface of ...
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Abstract
The invention relates to a micro-device for non-invasive and selective separation and extraction of particles in polydispersed suspensions by means of the strategic use of ultrasounds, laminar flow and standing wave effects in a channel produced in a chip by means of microtechnology. Said device is a resonant multi-layer system comprising a modified ''lambda quarter wavelength'' treatment channel, which enables the particles to be channelled and separated in a flow inside the substrate channel without touching the walls of the device, in order to avoid problems of adherence. Said micro-device can be used in the field of biomedicine and/or biotechnology for the separation and concentration of cells, preferably human cells, that can be used for investigative and medical methods for diagnosis and treatment.
Description
technical field [0001] The present invention relates to a device that combines microtechnology and ultrasound as a method for the selective separation and extraction of particles in polydisperse suspensions containing particles with different physical properties (size, Density or compressibility), the device is mainly applicable in the fields of biomedicine and biotechnology. Background technique [0002] During the past 10 years, different techniques for manipulating or separating suspended particulate matter have been proposed in different technological applications, especially in fields such as biotechnology and pharmacy. The separation of particles is currently of particular interest in medical applications related to blood donation, dialysis procedures and laboratory analysis, as well as the recirculation and / or washing of blood after surgery. [0003] The application of a standing acoustic wave to the suspension has the effect of transporting the particles to certain ...
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IPC IPC(8): B01D43/00B01J8/16A61M1/34
CPCB29L2031/756C12M41/02B01L3/502753B03B5/00A61B8/48A61B8/085C12N1/02B01D21/283A61B8/4444C12M23/16B29C66/028B01J2219/00932B29C65/02B29C66/53461C12M47/04Y10T156/1039A61M1/3678A61M1/34B01D43/00B01J8/16
Inventor 马里亚·伊西亚尔·冈萨雷斯戈麦斯托马斯·戈麦斯阿尔瓦雷斯-阿雷纳斯路易斯·乔斯·费尔南德斯莱德斯马阿尔弗雷多·卡拉托梅纳乔斯·路易斯·索托马丁内斯哈维尔·贝甘佐鲁伊斯
Owner CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
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