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38 results about "Microtechnology" patented technology

Microtechnology is technology with features near one micrometre (one millionth of a metre, or 10⁻⁶ metre, or 1μm). Around 1970, scientists learned that by arraying large numbers of microscopic transistors on a single chip, microelectronic circuits could be built that dramatically improved performance, functionality, and reliability, all while reducing cost and increasing volume. This development led to the Information Revolution.

Reflection-type confocal CARS micro-spectrum test method and device

The invention belongs to the technical field of micro-spectrum imaging detection, and relates to a reflection-type confocal CARS micro-spectrum test method and a device. According to the reflection-type confocal CARS micro-spectrum test method, fusion of laser confocal microtechnique and CARS spectrum detection technology is realized, a binary beam splitting system is adopted for nondestructive separation of Reyleigh scattering light and CARS light, wherein CARS light is used for spectrum detection, and Reyleigh scattering light is used for geometric positioning. Accurate capturing and positioning of exciting light focal point position is realized based on the corresponding performance of confocal curve top point to focal point, high precision geometric detection and high spatial resolution spectrum detection are realized, and the method and the device capable of realizing sample microdmain high spatial resolution spectrum detection are constructed. The intensity of sample information-loaded Raman scattering light excited via combination of CARS microtechnique is much higher than that of conventional spontaneous Raman light, excitation time is short, and possibility is provided for rapid detection of biological samples and chemical materials. The reflection-type confocal CARS micro-spectrum test method possesses advantages such as accurate positioning, high spatial resolution, high spectrum detection sensitivity, and controllable measuring focusing spot size; and application prospect in the fields such as biomedicine and material detection is promising.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Super-resolution microscopic imaging system

PendingCN112858250AMeet the experimental configuration requirementsHigh precisionFluorescence/phosphorescenceMedicineSingle molecule localization
The embodiment of the invention discloses a super-resolution microscopic imaging system. The system comprises an excitation light source generation module, an imaging module, a focal plane locking module and a control and data acquisition module, wherein the excitation light source generation module is used for generating an excitation light source; the imaging module is used for receiving the excitation light source, enabling the excitation light source to irradiate a sample on the sample slide to enable a view field area of the sample to generate fluorescent light, and collecting the reflected fluorescent light through the camera; the focal plane locking module is used for emitting laser to the imaging module and receiving the laser reflected by the imaging module so as to lock the distance between an objective lens in the imaging module and a sample slide; and the control and data acquisition module is used for controlling and adjusting optical elements in the excitation light source generation module, the imaging module and the focal plane locking module, and acquiring fluorescence data obtained by the imaging module for data analysis. According to the system, a compact, adjustable and controllable single-molecule positioning microtechnique with high automation degree is realized, and the precision and the accuracy are improved.
Owner:山东迈科显微生物科技有限公司

Multicolor structured light illumination super-resolution microscopic imaging method and device based on DMD

The invention discloses a multi-color structured light illumination super-resolution microscopic imaging method based on a DMD (Digital Micromirror Device), which is characterized in that the DMD is used as a digital blazed grating to diffract laser with different wavelengths, and positive and negative first-order diffraction light generated by Fourier filtering is subjected to accurate polarization modulation and then interferes on the surface of a fluorescent sample to be detected to generate a high-contrast stripe illumination pattern; fringe patterns in different directions and phases are loaded through the DMD to quickly perform direction rotation and phase movement on interference fringes, and a plurality of obtained original fluorescence intensity images are reconstructed to obtain a super-resolution microscopic image. The invention further discloses a multi-color structured light illumination super-resolution microscopic imaging device based on the DMD, different laser wavelengths are rapidly switched by a galvanometer to be gated or cut off to enter different square-core multimode optical fibers, and the incident angles of all the wavelengths are aligned by adjusting the output ends of the square-core multimode optical fibers. Therefore, the blaze level corresponding to each wavelength is ensured to be located at the same position so as to facilitate Fourier filtering. The device is low in complexity and high in flexibility, stability and expandability, and meanwhile, a modular design is adopted, so that the system can be extensively applied to imaging research of a three-dimensional interference type structure illumination obvious microtechnology and a projection type structure illumination obvious microtechnology.
Owner:ZHEJIANG UNIV

Sub-nanoscale high-precision micro-displacement device capable of being calibrated and application of sub-nanoscale high-precision micro-displacement device

ActiveCN114252002AElimination of open-loop nonlinear controlUsing electrical meansUsing optical meansCapacitanceLoop control
The invention provides a calibratable sub-nanoscale high-precision micro-displacement device and application thereof, and has the following beneficial effects that open-loop nonlinear control caused by inherent hysteresis and creep characteristics of a piezoelectric actuator can be effectively eliminated through piezoelectric closed-loop control based on capacitance micrometer feedback; in order to realize high-precision micro-displacement control of sub-nano-scale resolution capability, but the control capability still stays at a qualitative resolution level and cannot be used as a positioning reference in the field of precision positioning, the FP cavity equipped on the micro-displacement device can realize quantitative calibration of sub-nano-scale resolution capability micro-displacement on a high-performance spectrograph; the calibration result can be traced to the FP cavity transmission spectrum peak spacing so as to establish the quantitative calibration relationship between the applied voltage on the piezoelectric actuator and the sub-nanometer magnitude resolution capability micro displacement. Therefore, the problems of quantitative calibration of piezoelectric closed-loop control sub-nanometer magnitude resolution and nanoscale high-precision micro-displacement control based on a capacitance micrometer technology can be effectively solved.
Owner:HANGZHOU INST FOR ADVANCED STUDY UCAS

A kind of multi-layer slow-release microsphere preparation loaded with VEGF and vancomycin, preparation method and application

A kind of multi-layer topical slow-release microsphere preparation loaded with sodium alginate and chitosan and loaded with VEGF and vancomycin, its preparation method and its application in the preparation of medicines for treating bone defects, bone tissue regeneration and wound healing application. The invention belongs to the technical field of drug slow-release microspheres. In the present invention, except that the preparation of the core sphere is a dripping method, the preparation of the other multilayer microspheres is based on the principle of mutual attraction of positive and negative charges and layer-by-layer self-assembly. Sodium alginate and chitosan are both natural polymer polysaccharides. Chitosan is a polycationic polymer material with a large number of free amino groups in the side chain structure; and sodium alginate is a polyanionic material with a large number of carboxyl groups on the molecular side chain. , the two undergo a complexation reaction through the mutual attraction of positive and negative charges, and are sequentially wrapped to form multi-layer balls of core-shell type multi-layer sustained-release drugs according to the principle of layer-by-layer self-assembly, so that the product of the present invention can simultaneously promote local angiogenesis and improve blood circulation. And the effect of controlling local infection.
Owner:JILIN UNIV

Obvious micro -imaging system based on dual -core optical fiber light control and dynamic scattered spots

The invention provides a microscopic imaging system based on double-core optical fiber optical manipulation and dynamic speckle illumination. The utility model is characterized in that: the light manipulation part of the device is composed of two two-core optical fibers whose output end faces are processed into a specific angle and installed opposite to each other. The laser beams are respectively coupled into a two-core fiber through a single-mode fiber to form a focused light field near the output end face to stably capture the cells to be tested. By adjusting the output power of each core of the other two-core fiber, the cell is rotated about a specific axis. After the cells rotate to a certain angle and reach a stable state, the tomographic images of the cells are obtained by using dynamic speckle illumination widefield fluorescence microscopy, and finally the three-dimensional structural images of the cells are reconstructed. The system constructed by the invention can realize the acquisition of three-dimensional structural images of living single cells with high temporal and spatial resolution, has the characteristics of simple structure, low cost, simple operation, etc., and has a wide range of research fields such as biology, medicine and life sciences. application prospects.
Owner:GUILIN UNIV OF ELECTRONIC TECH
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