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Reflection-type confocal CARS micro-spectrum test method and device

A spectroscopic testing and reflective technology, used in measurement devices, Raman scattering, material analysis by optical means, etc., can solve problems such as restricting applications and limiting the ability of CARS microscopy systems to detect micro-area spectra, to improve the space The effect of resolving power, improving spectral detection sensitivity, and improving flexibility

Active Publication Date: 2017-07-28
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology

[0009] The above reasons limit the ability of the CARS microscope system to detect micro-region spectra, and restrict its application in finer micro-region spectrum testing and analysis occasions

Method used

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  • Reflection-type confocal CARS micro-spectrum test method and device
  • Reflection-type confocal CARS micro-spectrum test method and device
  • Reflection-type confocal CARS micro-spectrum test method and device

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Embodiment

[0053] In this embodiment, a picosecond laser with a wavelength of 1064nm is used as the pump light source and a probe light source, and a supercontinuum picosecond laser with the same repetition rate is used as a Stokes light source with a bandpass filter of 1100-1300nm , mixed and emitted under the conditions of space coincidence and time consistency, and tightly focused on the sample through a high-magnification microscope objective lens. At this time, the phase matching condition is met, and the anti-Stokes scattered light (CARS) with a wavelength range of 900-1030nm is excited. ).

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Abstract

The invention belongs to the technical field of micro-spectrum imaging detection, and relates to a reflection-type confocal CARS micro-spectrum test method and a device. According to the reflection-type confocal CARS micro-spectrum test method, fusion of laser confocal microtechnique and CARS spectrum detection technology is realized, a binary beam splitting system is adopted for nondestructive separation of Reyleigh scattering light and CARS light, wherein CARS light is used for spectrum detection, and Reyleigh scattering light is used for geometric positioning. Accurate capturing and positioning of exciting light focal point position is realized based on the corresponding performance of confocal curve top point to focal point, high precision geometric detection and high spatial resolution spectrum detection are realized, and the method and the device capable of realizing sample microdmain high spatial resolution spectrum detection are constructed. The intensity of sample information-loaded Raman scattering light excited via combination of CARS microtechnique is much higher than that of conventional spontaneous Raman light, excitation time is short, and possibility is provided for rapid detection of biological samples and chemical materials. The reflection-type confocal CARS micro-spectrum test method possesses advantages such as accurate positioning, high spatial resolution, high spectrum detection sensitivity, and controllable measuring focusing spot size; and application prospect in the fields such as biomedicine and material detection is promising.

Description

technical field [0001] The invention belongs to the technical field of microspectral imaging, and relates to a reflective confocal CARS microspectral testing method and device, which can be used to quickly detect micro-area anti-Stokes scattering (CARS) spectra of various samples, and can realize high Spatially resolved geometric imaging and detection can obtain high spatially resolved "image-spectrum integration" images. [0002] technical background [0003] Optical microscopes are widely used in the fields of biomedicine and material science. With the rapid development of modern science, the requirements for microscopic imaging have shifted from structural imaging to functional imaging. In 1990, the successful application of confocal Raman spectroscopy greatly improved the possibility of exploring the specific composition and morphology of tiny objects. It combines confocal microscopy technology and Raman spectroscopy technology. It has the high-resolution tomographic ima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/65G01N2021/653
Inventor 赵维谦黄伟华王允邱丽荣
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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