34results about How to "Realize tomography" patented technology

The invention belongs to the technical fields of optical microscopy imaging and optical precision measurement and relates to a laser differential confocal spectrum microscopy tomography device which mainly comprises a Raman spectrum analysis part (25) and an objective lens (6), a polarizing spectroscope (7), a one-quarter glass slide (8) and a measurement objective lens (9) which are sequentially arranged along the optical path; the laser differential confocal spectrum microscopy tomography device further comprises a differential confocal detection part (26) which is positioned in the reverse direction of the reflection direction of the polarizing beam splitter. The differential confocal detection part is used for measuring the geometric position of a micro-area of a sample and focusing the sample to obtain image information of the micro-area of the sample; the Raman spectrum analysis part is used for analyzing the material spectrum of the detected area of the sample to obtain component information of the micro-area of the sample; the combination of the two parts can realize the nano-level micro-area spectrum measurement of the sample and simultaneously obtain the geometric feature and the material component information of the micro-area of the sample. The laser differential confocal spectrum microscopy tomography device provides a powerful observation means for bio-medicine, material science, high-energy physics and other forefront subjects.

The invention belongs to the field of a microimaging and spectral measurement technology and relates to a laser differential confocal Brillouin-Raman spectroscopy measuring method and a device thereof which can be used in micro-area morphological parameter comprehensive test and high-resolution imaging of a sample. According to the method and the device, a differential confocal technology is incorporated into spectrum detection. Sample position detection is performed by the differential confocal technology; spectrum detection is conducted by a spectrum detection system; and properties, such as elasticity, piezoelectricity and the like, of a material are tested by the use of brillouin scattering light abandoned by a traditional confocal Raman spectrum detection technology. Thus, micro-area high-spatial resolution morphological parameter measurement of a sample is realized. The method and the device have advantages of accurate positioning, high spatial resolution, high spectrum detection sensitivity, controllable measured focusing spot size and the like, and have a wide application prospect in fields of biomedicine, evidence obtaining in court, micro and nano-fabrication, materials engineering, engineering physics, precision metrology, physical chemistry and the like.

The invention belongs to the technical field of spectrum measurement, and relates to a high spatial resolution biaxial differential confocal spectrum imaging method and an apparatus. According to the present invention, the biaxial differential confocal microscopy technology and the spectrum detection technology are fused, focal spot cutting differential detection is adopted so as to achieve precise imaging of the geometry position, simplify the optical path structure of the traditional differential confocal microscopy system, inherit the advantages of large visual field and large work distance of the biaxial microscopy technology, and achieve high spatial resolution spectrum integrated detection of the system; and high spatial resolution is provided, three modes such as three-dimensional tomography geometry imaging, spectrum detection and micro-region spectrum tomography imaging are provided, a new solving approach is provided for micro-region spectrum detection, and broad application prospects are provided in the fields of biomedicine, physical material science and the like.

The invention discloses a method and device for adaptively scanning tomographic microimaging with wide view field and high-throughput, and belongs to the technical field of microimaging. According tothe method, the target imaging area of a sample is divided into a plurality of sub-areas by utilizing ultrashort pulse laser through a method of combining spatial and temporal focusing and scanning, each sub-area is quickly and adaptively scanned by adopting a time division multiplexing method, synchronous data collection is carried out, reconstruction and data processing are performed on collected microimages in each sub-area to obtain a three-dimensional spatial message of the target scanning area in a scanning cycle, and the four-dimensional information of a sample (x, y, z and t) is acquired through three-dimensional spatial scanning and delayed scanning. The device comprises an ultrashort pulse laser light source and beam conversion system, a sub-area scanning system combined with thespatial and temporal focusing technology, an optical microscopic and filter system, a synchronous microimaging system and an image reconstruction and data processing system. The device has the advantages of wide view field, high throughput, low exciting power, high signal-to-noise ratio and the like.

The invention provides a multielement array electronic scan bio-organization photoacostic layer separating imaging method and the equipment, including the steps: the pulse laser comes into the bio-tissue to produce photoacoustic signal which is collected and stored by computer; use multielement array electronic scan detector receives the photoacoustic signal, synchronously, and at the same time the computer collects and stores the photoacoustic signal; repeat collection until all the group elements are collected once; after finishing collecting, the computer makes filtering and integral processing on the optical-voice signal, and then performs layer separating imaging on the bio-organization by backward projecting algorithm. The equipment includes the laser, the multielement array electronic scan detector, the high-speed collection card and the computer. The equipment's automation level is high, convenient to operate and simpler to control and use.

The invention belongs to the technical field of micro-spectral imaging detection and relates to a method and device for testing a spectral pupil laser differential confocal CARS micro-spectrum. The core thought is as follows: Rayleigh light and CARS light loaded with tested sample spectral characteristics are excited by double lasers as a light source; and nondestructive separation is carried out on the Rayleigh light and the CARS light by using a dichroic optical system, wherein the Rayleigh light is subjected to geometrical detection and positioning, and the CARS light is subjected to spectrum detection. By using the characteristic that a zero crossing point of the spectral pupil laser differential confocal curve accurately corresponds to a focus position, the focus position of an excitation beam is accurately captured and positioned, and high-precision geometrical detection and high-spatial-resolution spectrum detection are achieved to form the method and device capable of achieving high-spatial-resolution spectrum detection of a sample micro-region. Through combining a CARS microscopical technique, the excited Raman scattering light loaded with sample information is shorter than a traditional spontaneous Raman effect in time, and the sample can be quickly subjected to nondestructive detection. The method and the device have the advantages of accurate positioning, high spatial resolution, nondestructive detection and high spectrum detection sensitivity, and a new way is provided for micro-region spectrum detection and geometrical measurement.

The invention provides a scanning method for achieving high-resolution large-view-field CL imaging of plate-shaped samples. The method includes the steps that parameters are input, the number and the mode of spliced subimages are adjusted and determined, data are collected and spliced, and results are output. Projection data are collected through segmented scanning of the plate-shaped samples under the high-amplification-ratio condition, and high-resolution large-view-field faulted images of the large-area plate-shaped samples are finally obtained through the image splicing method in a square field-character-shaped or hexagonal honeycomb-shaped mode.

The present invention belongs to the technical field of spectral measurement and imaging, and relates to a laser differential confocal induced breakdown spectroscopy-Raman spectroscopy imaging detection method and a laser differential confocal induced breakdown spectroscopy-Raman spectroscopy imaging detection apparatus, wherein the method and the apparatus can be used for high spatial resolution imaging and detection of micro-region components and morphological parameters of samples. According to the present invention, with the method and the apparatus, the laser induced breakdown spectroscopy is used to detect the element composition information of the sample component, the Raman spectroscopy is used to detect the chemical bonds and the molecular structure information of the sample, the differential confocal technology is used to detect the sample surface morphology information and precisely position the focus position to ensure the minimum excitation light spot so as to improve the spatial resolution of the spectral detection, and the three technology can be combined to achieve the structure sharing and the function complementing so as to form the image and spectrum integrated high spatial resolution spectral imaging detection method and the image and spectrum integrated high spatial resolution spectral imaging detection apparatus; and the method and the apparatus have advantages of high spatial resolution, rich material component information, controllable focusing light spot size measuring and the like, and have wide application prospects in the fields of mineral resources, metallurgy, space exploration, environmental monitoring, biomedicine and the like.

The invention belongs to the technical field of micro-spectrum imaging detection, and relates to a reflection-type confocal CARS micro-spectrum test method and a device. According to the reflection-type confocal CARS micro-spectrum test method, fusion of laser confocal microtechnique and CARS spectrum detection technology is realized, a binary beam splitting system is adopted for nondestructive separation of Reyleigh scattering light and CARS light, wherein CARS light is used for spectrum detection, and Reyleigh scattering light is used for geometric positioning. Accurate capturing and positioning of exciting light focal point position is realized based on the corresponding performance of confocal curve top point to focal point, high precision geometric detection and high spatial resolution spectrum detection are realized, and the method and the device capable of realizing sample microdmain high spatial resolution spectrum detection are constructed. The intensity of sample information-loaded Raman scattering light excited via combination of CARS microtechnique is much higher than that of conventional spontaneous Raman light, excitation time is short, and possibility is provided for rapid detection of biological samples and chemical materials. The reflection-type confocal CARS micro-spectrum test method possesses advantages such as accurate positioning, high spatial resolution, high spectrum detection sensitivity, and controllable measuring focusing spot size; and application prospect in the fields such as biomedicine and material detection is promising.

The invention discloses composite nanoparticles with tumor targeting and radiotherapy sensitization characteristics, and preparation and application of the composite nanoparticles. The composite nanoparticles comprise hyaluronic acid, bismuth trioxide and cerium oxide which grow on the hyaluronic acid. The synthesized composite nanoparticles with the tumor targeting and radiotherapy sensitizationcharacteristics have good water dispersibility and biocompatibility, sensitization and radiotherapy are conducted through two aspects of enhancing local radiation dose of tumor by the bismuth trioxideand improving the tumor hypoxia by the cerium oxide, and meanwhile, computed tomography, magnetic resonance and photoacoustic multi-mode imaging radiography can be achieved; the preparation method issimple, conditions are mild, controllability is good, an additional organic stabilizer/dispersant does not need to be added, and implement and promotion are easy; and the integration of tumor targeted radiotherapy and sensitization diagnosis and treatment can be achieved, and wide application prospects in the fields of nano medicine, disease diagnosis and tumor treatment and the like are achieved.

The invention discloses a near-infrared two-zone confocal microscopic imaging system based on a multi-dimensional adjustment frame. According to the invention, a confocal microscope module is installed on a multi-dimensional adjustment frame, and an objective lens can be conveniently moved directly above the imaging plane through multi-dimensional translation and rotation. Near infrared laser is introduced from the port on a scanning unit and realizes scanning in the X-Y plane through a scanning galvanometer. Outgoing fluorescence is filtered out of focus signal in a pinhole module and finallydetected by a photomultiplier tube with near infrared two-zone response. The objective lens is installed on an electric focusing module, which can realize accurate focusing and tomography. Accordingto the invention, the multidimensional adjustment frame can be adopted to enable a confocal microscope to conveniently image large animals, and the performance is improved by optimizing the imaging band. The system of the invention has the advantages of excellent performance and simple use, and is suitable for promotion.

A real-time optico-acoustic imaging method based on acoustic lens and reflecting film detection is disclosed. The acoustic lens is used to generate the acoustic pressure distribution of biologic tissue duto optico-acoustic effect and couple it to an imaging plane for directly imaging on it. A multi-layer reflecting film is used to convert said acoustic pressure distribution to light intensity distribution, which is recorded by CCD to obtain a clear image of a tissue layer. Its apparatus is composed of transparent flexible rubber layer, optical fiber, acoustic lens, two lasers, sound-transmission opaque material, multi-layer reflecting film, CCD, computer, and cylindrical cavity made of aluminum.

An optoacoustic imaging and tomographic imaging method based on acoustic lens includes such steps as using pulse laser beam to irradiate biologic tissue to generate MHz-class ultrasonic (optoacoustic signal), using acoustic lens to image the laser beam excited acoustic pressure of biologic tissue and the acoustic pressures of different layers on the imaging planes, detecting the acoustic pressure distribution on some imaging plane by 2D plane array of optoacoustic sensors to obtain optoacoustic signals, and reconfiguring the tissue image of some layer. Its apparatus is composed of transparent and flexible rubber layer, optical fiber, acoustic lens, 2D plane array of optoacoustic sensors, output circuit, delay-signal conversion circuit, acquisition card and computer.

The invention provides a cornea surface contour obtaining system and a use method thereof. The system comprises a shell, an optical projection unit, an optical shooting unit, a control panel and a display screen; the optical projection unit is arranged in the shell and used for projecting tandem arranged light rays into the human eye; the optical shooting unit is arranged in the shell and used for collecting light rays reflected from the human eye; the control panel is arranged in the shell and connected with the optical projection unit and the optical shooting unit; the display screen is arranged in the shell and connected with the control panel and the optical shooting unit. The cornea surface contour obtaining system and the use method thereof have the following advantages that surface contour data of the front surface and the rear surface of a cornea are obtained simultaneously, and the surface contour accuracy is greatly improved, particularly, in the central area of the cornea; complex rotary motion is not needed, tomoscan in all directions can be achieved by only depending on control over micromirror devices, the scanning speed is high, and the cornea surface contour data can be rapidly obtained; the size is small, and carrying and using can be convenient for a doctor.

The application discloses an ultrasonic detection device and an ultrasonic transducer. The ultrasonic detection device comprises a ultrasonic transducer, a clamping assembly and a driving assembly, wherein the ultrasonic transducer is used for performing tomography on a workpiece to be detected and comprises a plurality of independent array elements, the plurality of array elements are surroundedinto a tubular object for one end of the workpiece to be detected to penetrate through, and the radiation surfaces of the plurality of array elements form the inner side wall of the tubular object; the clamping assembly is used for clamping the other end of the workpiece to be tested; and the driving assembly is connected with the clamping assembly and used for driving the clamping assembly to move. The ultrasonic detection device can be used for carrying out 360-degree tomography on a workpiece to be detected.