Flurbiprofen-containing external patch

A flurbiprofen and patch technology, which is applied in the field of flurbiprofen topical patches, can solve problems such as skin irritation, pasty residue, adhesive cohesion damage, etc., achieve formulation stabilization, and inhibit crystallization , The effect of stabilizing transdermal absorption

Active Publication Date: 2011-04-27
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the volatile 1-menthol volatilizes during storage, resulting in the possibility of crystallization of flurbiprofen as the main ingredient
[0010] In addition, in Patent Document 5 (JP-A-7-309749), a rubber-based adhesive using lactic acid ester as a flurbiprofen dissolving agent is disclosed. When formulated, the solvent may leave a pasty residue on the skin, and may also be a cause of skin irritation

Method used

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  • Flurbiprofen-containing external patch
  • Flurbiprofen-containing external patch
  • Flurbiprofen-containing external patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0047] Examples 1-4 / Comparative Examples 1-3

[0048] According to the above-mentioned production method, patch preparations based on the mixed prescriptions in Table 1 (Examples 1 to 4) and Table 2 (Comparative Examples 1 to 3) below were obtained.

[0049] Table 1

[0050]

[0051] Table 2

[0052]

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PUM

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Abstract

The invention provides a percutaneous absorption external patch formed by laminating an adhesive layer on a support body. The adhesive layer contains styrene-isoprene-styrene (SIS) block copolymer, tackifying resin and a softener which are taken as essential components, and flurbiprofen which is taken as an active ingredient is mixed with the essential components. In the flurbiprofen-containing external patch, flurbiprofen is possibly released for a long term stably, and the preparation has high stability and extremely high medicament release property.

Description

[0001] This application is a divisional application of Chinese patent application No. 200580048135.4. The filing date of the patent application No. 200580048135.4 is February 28, 2005. The title of the invention is "external patch containing flurbiprofen". technical field [0002] The present invention relates to an adhesive containing styrene-isoprene-styrene block copolymer (SIS), a tackifying resin, and a softener as essential components, in which flurbiprofen is mixed as an active ingredient external patches. Background technique [0003] Flurbiprofen, one of non-steroidal analgesic and anti-inflammatory agents (NSAIDs), is widely used in chronic joint rheumatism, osteoarthritis, shoulder arthritis, low back pain, tenosynovitis, muscle pain, etc. Administration methods include oral administration in dosage forms such as tablets and granules, and transdermal administration in dosage forms such as ointments and patches. [0004] In the case of oral administration preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/192A61K47/32A61K47/44A61P29/00
Inventor 山地正博菅原贵也
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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