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Compound solid preparation for treating asthma

A technology for solid preparations and compound recipes, applied in the field of pharmaceutical preparations, can solve problems such as ineffectiveness, and achieve the effects of simple process, low production cost and easy portability

Inactive Publication Date: 2011-05-18
天津金世制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Strains producing β-lactamase are not effective for this product

Method used

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  • Compound solid preparation for treating asthma
  • Compound solid preparation for treating asthma
  • Compound solid preparation for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: (tablet) (quantity of 100 pieces)

[0021]

[0022] Pass the main drug and auxiliary materials through a 100-mesh sieve respectively, fully mix, then weigh the prescription amount of auxiliary materials and fully mix with the main drug. Then add starch slurry to make soft material, granulate with a 20-mesh sieve, dry at 55°C, and granulate with a 18-mesh sieve. Finally, add the lubricant and mix evenly for tableting.

Embodiment 2

[0023] Embodiment 2 (dispersible tablet) (100 pieces amount)

[0024]

[0025]

[0026] Pass the main drug and auxiliary materials through a 100-mesh sieve respectively, fully mix, then weigh the prescription amount of auxiliary materials and fully mix with the main drug. Then add binder to make soft material, granulate with 20-mesh sieve, dry at 55°C, and granulate with 18-mesh sieve. Add lubricant and remaining carboxymethyl starch sodium at last and mix and compress evenly.

Embodiment 3

[0027] Embodiment 3: (orally disintegrating tablets) (quantity of 100 tablets)

[0028]

[0029] Pass the main ingredient and auxiliary materials through a 100-mesh sieve, mix thoroughly, press the cake with a roller press, and then use a sizing agent to pass through a 18-mesh sieve for granulation, and finally add a lubricant and mix evenly for tableting.

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PUM

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Abstract

The invention relates to a compound solid preparation for treating asthma, which consists of ambroxol hydrochloride and azithromycin which serve as active ingredients and auxiliary materials, wherein the ratio of the ambroxol hydrochloride to the azithromycin is 2:1-10:1, the weight ratio of the active ingredients to the auxiliary materials is 1:5-100, and preferably the medicament content of each single dose is 7.5:2 to 30:12 mg. The oral solid preparation containing the ambroxol hydrochloride and the azithromycin which serve as the active ingredients has the characteristics of stability in storage, convenience for carrying, capability of reducing production cost, and suitability for large-scale production. The oral solid preparation has the obvious synergistic effect on the relief of symptoms such as dyspnea and the like caused by airway obstructive diseases such as bronchial asthma, chronic bronchitis, emphysema and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, more specifically, an oral solid preparation containing active ingredients of ambroxol hydrochloride and azithromycin Background technique [0002] The chemical name of ambroxol hydrochloride is: trans 4-[(2-amino-3,5-dibromo-phenyl)methyl-amino]cyclohexanol hydrochloride. Ambroxol hydrochloride is a new generation of airway mucus regulator, which has excellent expectorant effect and can significantly promote the synthesis and secretion of alveolar surfactant. Ambroxol hydrochloride can stimulate bronchial mucus glands to secrete more flowable mucus, dilute sputum, reduce viscosity, and increase the production and secretion of pulmonary surfactant, thereby reducing airway resistance, reducing mucus adhesion, and activating Mucociliary blanket functions to facilitate mucociliary transport. Compared with the first-generation and second-generation expectorant drugs, ambroxol hydrochlorid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7052A61K31/137A61P31/04A61P11/10A61P11/00A61P11/06
Inventor 宋富智
Owner 天津金世制药有限公司
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