Unlock instant, AI-driven research and patent intelligence for your innovation.

Clathrate compound of ginkgetin and cyclodextrin and application thereof

A technology of ginkgo flavonoids and cyclodextrin, which is applied in medical preparations of non-active ingredients, medical raw materials derived from ginkgo biloba, drug combinations, etc.

Inactive Publication Date: 2011-05-18
TIANJIN TIANCHENG PHARMA
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved in the present invention is: by using suitable cyclodextrin and / or the derivative of cyclodextrin and / or its mixture, carry out clathrate to ginkgo flavonoid, improve its physical property that ginkgo flavonoid is almost insoluble in water, Achieve the purpose of significantly improving the solubility of ginkgo flavonoids in water

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] At room temperature, treat 200 mg of ginkgo flavonoids in 20 ml of 40% hydroxypropyl-β-cyclodextrin for about 4 hours to obtain a slightly turbid solution, which is filtered with a 0.2 μ microporous membrane until it is clear, and the amount of ginkgo flavonoids in the solution is The concentration can be as high as 8-10mg / ml (the detection method is HPLC, and the detector is an evaporative light scattering detector). The solution was filled in ampoules, and the quality remained unchanged for 18 months after sterilization.

Embodiment 2

[0032] At room temperature, dissolve 30 g of hydroxypropyl-β-cyclodextrin in 80 ml of water, and treat 300 mg of ginkgo flavonoids for about 3 hours to obtain a slightly turbid solution. The solution is freeze-dried to obtain a white powder, which can be redissolved in water. It can be proved by differential scanning calorimetry that the white powder is in the form of clathrate, and the clathrate rate is 90%.

Embodiment 3

[0034] Ginkgo flavonoids 8 mg and β-cyclodextrin 76 mg are fully ground in 50% ethanol 5 until a uniform paste is formed, and a white powder is obtained after vacuum drying. .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a clathrate compound of ginkgetin and a cyclodextrin derivative, which consists of ginkgetin and cyclodextrin which serve as raw materials according to a weight ratio of 1:1-150. In water or a water-containing ethanol medium, the ginkgetin reacts with the cyclodextrin derivative, the obtained solution is filtered by a micropore filter membrane until the solution is clear, and the clathrate compound is separated from the mixture, or is prepared by high-energy grinding. The clathrate compound of the ginkgetin and the cyclodextrin improves the solubility of the ginkgetin in the water obviously, so various liquid preparations required by medical treatment can be prepared to meet clinical requirements.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to an inclusion complex formed by ginkgo flavonoids and cyclodextrin derivatives, a preparation method and application thereof. Background technique [0002] Ginkgo biloba extract Ginkgo biloba P.E is a light yellow-brown flowable brown-yellow powder with a slight scent of ginkgo leaves. Total flavonoid glycoside content: 24-26% (HPLC method), total terpene lactone content 8-10% (HPLC method) bilobalide ≥ 2.5% ginkgolide A ≥ 1.4% ginkgolide B ≥ 1.2%, ginkgolide Ester C ≥ 0.9%, increase cerebrovascular flow, reduce cerebrovascular resistance, improve cerebrovascular circulation, protect brain cells from ischemic damage, dilate coronary arteries, prevent angina pectoris and myocardial infarction, inhibit platelet aggregation, and prevent thrombosis. Eliminate harmful oxidative free radicals, improve immunity, and have anti-cancer and anti-aging functions. It ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K47/48A61P9/10A61P9/12A61P25/28A61K47/69
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA