Partial external use composition containing povidone Iodine and cyclodextrin inclusion glucocorticoid

A technology of glucocorticoids and povidone-iodine, which is applied to medical preparations containing active ingredients, drug combinations, skin diseases, etc., can solve problems such as delayed treatment, difficult treatment, and difficult to distinguish, and achieve improved stability and improved curative effect and reduce the incidence of misdiagnosis

Inactive Publication Date: 2011-06-01
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, allergic dermatitis caused by fungal infection and non-infectious allergic dermatitis are very similar in surface symptoms, and it is difficult to distinguish without microscopic examination, so it is easy to cause misdiagnosis in clinical practice, thus delaying treatment
For skin diseases caused by infections such as skin fungi, although glucocorticoids are not used in treatment, due to the sensitization of microorganisms such as fungi, it is often accompanied by the occurrence of allergic skin inflammation. Jia Dongmei et al. Influence, Foreign Medical Dermatology, Volume 29, No. 4, 2003, No. 4, 201-203) discloses that in skin fungal infection experiments, after antifungal drug treatment is used until the infection is eliminated, animals often still have inflammatory scabs. , indicating that skin inflammation is often more difficult to treat than the infection itself

Method used

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  • Partial external use composition containing povidone Iodine and cyclodextrin inclusion glucocorticoid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, the preparation of hydrocortisone cyclodextrin inclusion aqueous solution

[0042] Dissolve 10g of 3-hydroxypropyl-β cyclodextrin in 75ml of 95% ethanol at room temperature, add 1g of hydrocortisone, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 40ml of Water for injection, stirred for 5 minutes, concentrated under reduced pressure, and evaporated to remove ethanol to obtain an aqueous solution of hydrocortisone / 3-hydroxypropyl-β-cyclodextrin inclusion complex for future use.

Embodiment 2

[0043] Embodiment 2, the preparation of dexamethasone acetate inclusion aqueous solution

[0044] Dissolve 40g of hydroxyethyl-β-cyclodextrin in 100ml of acetone at room temperature, add 1g of dexamethasone acetate, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 10mL of water for injection, stir Concentrate under reduced pressure for 5 minutes, and distill off the acetone to obtain an aqueous solution of dexamethasone acetate / hydroxyethyl-β-cyclodextrin inclusion complex, which is set aside.

Embodiment 3

[0045] Embodiment 3, the preparation of mometasone furoate cyclodextrin inclusion aqueous solution

[0046] Dissolve 4g of 2-hydroxypropyl-β-cyclodextrin in 20ml of acetone at 40±2°C, add 1g of mometasone furoate, stir to dissolve, stir for another 30 minutes, filter through a microporous membrane (220nm), add 6mL water for injection, stirred for 5 minutes, and concentrated under reduced pressure. The concentration process was added twice, adding 8ml water for injection each time, and acetone was removed to obtain mometasone furoate / 2-hydroxypropyl-β-cyclodextrin inclusion aqueous solution ,spare.

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Abstract

The invention discloses a partial external use composition containing povidone Iodine and cyclodextrin inclusion glucocorticoid, which comprises povidone Iodine and glucocorticoid which serve as active components, and one or more of auxiliary materials which are suitable for skin administration; and the partial external use composition containing povidone Iodine and cyclodextrin inclusion glucocorticoid is characterized in that the glucocorticoid is included by beta-cyclodextrin or derivatives of the beta-cyclodextrin, the content of the povidone Iodine in the partial external use composition is 1%-10%.

Description

Technical field: [0001] The invention relates to a local external pharmaceutical composition with povidone iodine and glucocorticoid as active components. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are all allergic reactions caused by certain allergens, resulting in skin inflammation and skin allergies There are many kinds of allergens that react, among which infections such as viruses, fungi, and bacteria are one of the important causes of skin inflammation, Yuan Wei et al. Journal, February 2004, 24-25) disclosed that 96 of 136 patients with atopic dermatitis were diagnosed with fungal infection, and the literature believed that fungal infection was an important cause of various skin inflammations such as allergic dermatitis. sensitive factors. Glucocorticoids are widely used to treat skin inflammation. However, due to the immunosuppressive effect of glucocorticoids, when glucocorticoids are use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/79A61P17/00A61K31/56A61K31/573A61K31/58
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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