Lornoxicam tromethamine eutectic crystal

Abstract

The invention relates to a lornoxicam tromethamine eutectic crystal formed by combining lornoxicam and tromethamine. By Cu-K alpha radiation, characteristic peaks are presented at the positions of 7.80, 8.28, 9.64, 12.82, 13.76, 15.60, 16.96, 17.80, 18.22, 19.32, 20.18, 21.38, 23.20, 23.56, 25.36, 27.74, 31.60 and 32.28 of X-ray powder diffraction spectrum which is represented in a degree of 2 theta; absorption peaks are presented at the positions of about 3352, 3294, 3103, 2937, 2887, 1627, 1573, 1533, 1496, 1473, 1433, 1392, 1332, 1236, 1188, 1155, 1045, 887, 821, 777, 634, 588, 551,522 and 462 cm<-1> wavelengths of infrared absorption spectrum obtained by KBr tebletting; and heat absorption transformation of differential scanning caborimetry (DSC) is mainly generated at the temperature of about 55.9 DEG C. The lornoxicam tromethamine eutectic crystal disclosed by the invention is different from the existing commercial lornoxicam powder in the aspects of X-ray diffraction, DSC, infrared spectrum and melting point, thus the crystal form of the lornoxicam tromethamine eutectic crystal is a crystal form which is completely different from the lornoxicam prepared by the prior art. Compared with the lornoxicam physical mixture of equivalent tromethamine, the digestion speed and degree of the lornoxicam tromethamine eutectic crystal are obviously improved.

Description

Lornoxicam Tromethamine Cocrystal technical field The invention belongs to the technical field of medicine, and in particular relates to lornoxicam tromethamine co-crystal and a preparation method thereof. Background technique Lornoxicam, 6-Chloro-4-hydroxy-2-methyl-3-(2-pyridinecarbamoyl)-2H-thieno[2,3-e]-1,2-thiazine-1 , 1-dioxide (Lornoxicam), a thiazide derivative, is a non-steroidal anti-inflammatory analgesic, clinically used to treat acute and chronic pain caused by inflammation, such as postoperative pain, arthritis, rheumatism , soft tissue injury, etc. Lornoxicam inhibits the synthesis of prostaglandins by inhibiting the activity of arachidonic acid cyclooxygenase, so it has strong analgesic and anti-inflammatory effects. Lornoxicam has very little solubility in water, thus affecting its dissolution rate and bioavailability in water. Patent CN101185868 discloses a process for preparing lornoxicam fine particles using supercritical fluid crystallization techno...

AI Technical Summary

Problems solved by technology

Lornoxicam has very little solubility in water, thus affecting its dissolution rate and bioavailability in water

Images