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Preparation technology and production method of integrated minor bupleurum decoction novel dosage form

A technology of Xiaochaihu Decoction and a production method, which can be applied in the directions of anti-inflammatory agents, drug combinations, pharmaceutical formulations, etc., can solve the problems of few new substances, etc., and achieve the effects of strong sustained and controlled release performance and wide targeted distribution.

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in most cases, due to the small amount of the new substance, it only plays a synergistic or auxiliary effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles. The composition of the raw materials used to make the active ingredients is——

[0043] 30 parts of Bupleurum, 20 parts of Scutellaria, 30 parts of Codonopsis, 8 parts of Licorice, 15 parts of Pinellia, 10 parts of Ginger, and 25 parts of Jujube.

[0044] Its manufacturing process is as follows:

[0045] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according ...

Embodiment 2

[0047] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0048] The composition of the raw materials used to make the active ingredients is——

[0049] 30 parts of Bupleurum, 20 parts of Scutellaria, 30 parts of Codonopsis, 8 parts of Licorice, 15 parts of Pinellia, 10 parts of Ginger, and 25 parts of Jujube.

[0050] Its manufacturing process is as follows:

[0051] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pas...

Embodiment 3

[0053] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion. The composition of the raw materials used to make the active ingredients is——

[0054] 30 parts of Bupleurum, 20 parts of Scutellaria, 30 parts of Codonopsis, 8 parts of Licorice, 15 parts of Pinellia, 10 parts of Ginger, and 25 parts of Jujube.

[0055] Its manufacturing process is as follows:

[0056] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square cen...

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Abstract

The invention relates to a preparation technology and production method of an integrated minor bupleurum decoction novel dosage form. The integrated novel dosage form comprises the following active ingredients in parts by weight: 30 parts of bupleurum, 20 parts of scutellaria baicalensis, 30 parts of dangshen, 8 parts of radix glycyrrhizae preparata, 15 parts of pinellia tuber, 10 parts of ginger and 25 parts of Chinese dates. The production process comprises the following steps: extraction in aqueous alcohol, ultrasonic grinding and extraction, microwave extraction, decoction in water and concentration, supersonic spray drying, high-pressure homogenizing, nanoscale grinding, nanoparticle preparation and the like. In the method, the stress is laid on the advantages of multi-synergy and multi-target effects of nano traditional Chinese medicines. After scale industrial production, the production cost can be substantially lowered, the product quality can be improved and the targeting and slow / controlled release properties of the medicines are stronger. After the novel dosage form is prepared into films, the films can be stuck to the skins of the human bodies and are used for treating the diseases through percutaneous absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Xiaochaihu Decoction, and also relates to a preparation technology of a new integrated dosage form of Xiaochaihu Decoction and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. The backwardness of the level of preparations not only affects the efficacy of drugs, but also leads to low added value of drugs, which directly affects market competition and industrial economic benefits. This is why the number of products in my country's pharmaceutical industry ranks among the top in the world and the output value is only equivalent to one or two multinational pharmaceutical companies. One of the main reasons. The development level of new drugs and new dosage forms can reflect the economic and technical strength of a country's phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/00A61P1/16A61P11/00A61P13/12A61P15/00A61P29/00A61P31/06A61P33/06A61P35/00A61P37/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH