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Method of manufacturing solid solution peforator patches and uses thereof

一种可溶性、微型针的技术，应用在制造和生产固体溶液穿孔器,贴剂注入/插入领域，能够解决浇注方法不适用大规模生产、微型针阵列很贵、复杂等问题

Inactive Publication Date: 2011-06-22
THERAJECT INC.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fabrication of master microneedle arrays using MEMS can be expensive and complex, and polymeric microneedles may require drug loading or coating, making casting methods unsuitable for mass production

Method used

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  • Method of manufacturing solid solution peforator patches and uses thereof
  • Method of manufacturing solid solution peforator patches and uses thereof
  • Method of manufacturing solid solution peforator patches and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0089] Example 1: Fabrication of positive master and SSP from silicon mold

[0090] Figure 1D Shown in is the hole 114 made in the glass by chemically etching a through hole in the photoresist film formed by photolithography, and the acupuncture needle alignment and passage hole 114. The tip of the needle passing through the hole is described. Pour PDMS over this side and let it cure overnight. 8% sodium methylcellulose hydrogel was poured on the silicon mold, and then centrifuged at 3000 rpm for 5 minutes. After centrifugation, the hydrogel was dried for one day and peeled from the mold. Figure 5 is an image of dissolvable microneedles made from cellulose. Figure 1F Additional micro-molds fabricated using CNC contouring grinder technology are described in .

example 2

[0091] Example 2: Compression break force and dissolution time of different components

[0092] Compression testing was performed with a dynamometer (NexyGen DF series), measuring the conical compressive force exerted by the microneedle upon snapping off. Test samples were prepared using different carbohydrate derivatives and sodium carboxymethylcellulose (SCMC). Mix 8% SCMC with deionized water. The time for complete dissolution of SCMC in 10 ml of deionized water at 300 rpm was measured. The results were weight normalized since the carbohydrate derivatives were added to fixed 8% SCMC hydrogels. The results are shown in Table 1.

[0093] Table 1

[0094]

[0095]

example 3

[0096] Example 3: Mechanical properties of different lactose components

[0097] Compression and dissolution tests were performed on different lactose components. When lactose was added, the tested granules dissolved faster and the compressive force increased. See Table 2.

[0098] Table 2

[0099]

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PUM

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Abstract

Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and / or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and / or post-drying processes.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit under 35 U.S.C. §119(e)(1) of U.S. Provisional Application No. 61 / 128,405, filed May 21, 2008, the entire contents of which are hereby incorporated by reference. technical field [0003] The present invention generally relates to methods of fabricating and producing solid solution perforators (SSPs), such as soluble microneedles from sharp metal, or glass needles, or precision machining and / or subsequent molding. In particular, the present invention relates to a method of producing a micro-mold structure made of cured material from a fine needle array alinment and its use. Furthermore, the present invention relates to a method of improving the mechanical strength of microneedles by designing a flexible microneedle patch, and a method of patch injection / insertion and use thereof. Background technique [0004] Transdermal or intradermal drug delivery, including the delivery of protein...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/06
CPCA61M2037/0046A61B2017/00761A61B2017/00345A61B17/205A61M37/0015B29C33/0027A61M2037/0023A61M2037/0061A61M2037/0053B29C33/3885B29C33/308B29C33/3878B29C33/0033
Inventor 吴世镇权圣润
Owner THERAJECT INC.
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