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Hazardous substance removing material and method for removing hazardous substance

A technology for harmful substances and substances, applied in the field of harmful substances removal materials, can solve the problems of time-consuming inactivation, bacteria detachment, resurrection and infection of the human body, etc., to improve anti-corrosion properties, increase effective dose, and improve the ability to capture airborne bacteria. effect of speed

Inactive Publication Date: 2011-06-29
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when removing by adsorption, if harmful substances are bacteria, viruses, etc., bacteria that have been captured with the filter may escape from it to revive and infect the human body
In addition, with regard to the method of inactivating harmful substances by passing them through a titanium oxide or strong acid sterilization zone, there is a problem that the inactivation is somewhat time-consuming and the effect obtained thereby is not necessarily sufficient
However, International Publication WO2005 / 35586 does not relate to harmful substance removal materials loaded with antibodies

Method used

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  • Hazardous substance removing material and method for removing hazardous substance
  • Hazardous substance removing material and method for removing hazardous substance
  • Hazardous substance removing material and method for removing hazardous substance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] (preparation of carrier)

[0085] An acetone / water (97:3) solution (25% by mass) containing cellulose acetate (total degree of substitution: 2.4; number average molecular weight: 30,000; produced by Aldrich) was heated to 60° C., and then spun at 500 m / m Spinning rate and air were sprayed from a nozzle with a diameter of 0.1 mm to form a nonwoven fabric. Thus, a nonwoven fabric N-1 having a film thickness of 85 μm was obtained. A spinning cylinder was heated to 100° C. with a heater. The average fiber diameter was measured by SEM and found to be 8 μm.

[0086] (preparation of antibodies)

[0087] 0.5 mL of antigen solution containing inactivated influenza virus (100 μg) was mixed with 0.5 mL of complete adjuvant. The resulting mixture was inoculated on the breast muscles of ostriches for the first immunization. For the second and subsequent immunizations, 0.5 mL of the same above-mentioned antigen solution was mixed with 0.5 mL of incomplete adjuvant, and the resul...

Embodiment 2

[0109] In addition to further uniformly mixing the hydrophilic polymers shown in Table 2 in the one-step coating method of Example 1 using fucose α-1,6-N-acetylglucosamine (which will be shown in Table 2 Except that the amount of the coated antibody in the test system was previously adjusted to a constant value), samples were prepared and evaluated by the same method as above. In addition, the obtained filter samples were left to stand at 60° C. and 90% RH for one week, and then evaluated. For comparison, a standard product (R-1) containing no sugar chain affinity substance was also evaluated.

[0110] In addition, the average thickness of the sugar chain affinity layer is measured by the following formula, which is obtained based on cylindrical approximation of fibers.

[0111] Average thickness=(mass of sugar chain affinity layer per unit area) / average density of composition / (2×fiber weight per unit area) / average fiber density·average fiber diameter)

[0112] Table 2

[0...

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Abstract

It is an object of the present invention to provide a hazardous substance removing material, which efficiently captures hazardous substances derived from microorganisms such as bacteria or viruses and rapidly inactivates them, so as to minimize the their influences on human bodies, and which is able to allow an antibody to be supported on a carrier by a simple method, and which has an improved antibody use efficiency. The present invention provides a hazardous substance removing material consisting of a carrier on which an antibody and a sugar chain affinity substance having an affinity for a sugar chain in the Fc region of the antibody are supported.

Description

technical field [0001] The present invention relates to a harmful substance removal material capable of selectively inactivating bacteria or viruses, and a method for removing harmful substances using the same. Background technique [0002] In recent years, infectious diseases caused by bacteria, molds, viruses, etc. have been recognized as social problems. For example, large numbers of infections in general public places such as hospitals and public facilities are of concern. Especially in the case of nosocomial infections, for example, MRSA (Methicillin-resistant Staphylococcus aureus) is caused by the abuse of antibiotics and the like. [0003] In view of the above problems, recent buildings are provided with ducts in each room in the manner of using air conditioners to circulate air through the ducts to control the room temperature or other conditions of the entire building. Thus, bacteria, mold, viruses, and the like floating in the facility are generally diffused thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24A61L9/01B01D39/14
CPCA61L2209/16A61L2209/14B01J20/3242B01J20/3274
Inventor 岩永宏
Owner FUJIFILM CORP
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