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Chinese medicinal composition for treating myasthenia gravis

A myasthenia gravis and composition technology, which is applied in the direction of drug combination, medical raw materials derived from arthropods, and pharmaceutical formulations, can solve problems such as unsatisfactory drug efficacy, undisclosed therapeutic effect, and low clinical cure rate.

Active Publication Date: 2011-07-13
南通集智知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prescription of the composition is complex, consisting of more than 20 traditional Chinese medicines, and the clinical cure rate is not high; Chinese patent application 200810105820.1 discloses a pharmaceutical composition composed of a variety of traditional Chinese medicines, but the medicine disclosed in the application is composed of 18 kinds of traditional Chinese medicines. The large compound prescription composed of medicinal materials, the prescription is also relatively complicated, and its medicinal effect is not very satisfactory
Chinese patent application 200810102291 also discloses a traditional Chinese medicine composition for treating myasthenia gravis, but does not disclose its therapeutic effect
[0004] Therefore, there is still a lack of a pharmaceutical composition for the treatment of myasthenia gravis with simple prescription, controllable quality and definite curative effect in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Astragalus 100g Bupleurum 5g Cistanche 10g

[0071] Schisandra 10g Epimedium 30g Jujube 5g

[0072] The pharmaceutical composition in the above parts by weight is ground and mixed uniformly, and appropriate amount of starch and magnesium stearate are added, and a small bag is made according to a conventional preparation method, and the specification is equivalent to containing 5g of raw medicinal material.

Embodiment 2

[0074] Astragalus 900g Bupleurum 50g Cistanche 80g

[0075] Schisandra 200g Epimedium 180g Jujube 85g

[0076] Take the above-mentioned weight of epimedium and jujube and grind them into fine powder; add five times the amount of water to decoct astragalus, bupleurum, cistanche, and schisandra respectively, two hours each time. Filtrate the combined filtrate, let it stand for 48 hours, take the supernatant and concentrate it under reduced pressure to form a clear paste with a relative density of 1.20, add the fine powder ground from Epimedium and jujube, mix evenly, and then granulate, the specification is equivalent to containing Raw medicinal materials 5g. The extraction yield is 20% based on the mass of the powder after crushing the clear paste.

Embodiment 3

[0078] Astragalus 600g Bupleurum 30g Cistanche 50g

[0079] Schisandra 60g Epimedium 130g Jujube 65g

[0080] Get the jujube of above-mentioned weight and grind into fine powder. Add astragalus, cistanche, and schisandra with five times the amount of water and decoct twice, each time for two hours. Filter and combine the filtrates, and after standing for 48 hours, take the supernatant and concentrate under reduced pressure to form a clear paste. Get the Bupleurum and Epimedium of the above weight and reflux twice with 60% ethanol, each time for one hour. The combined filtrates were concentrated under reduced pressure into a clear paste. After the obtained clear paste is pulverized and mixed with the fine powder obtained by grinding jujube, it is made into tablets by a conventional process, and the specification is equivalent to containing 5 g of raw medicinal materials. The extraction yield is 22% based on the mass of the powder after crushing the paste.

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PUM

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Abstract

The invention provides a Chinese medicinal composition for treating myasthenia gravis. The composition basically comprises astragalus root, bupleurum, desertliving cistanche, epimedium, Chinese date and schisandra. Meanwhile, the invention also provides a composition which has improved effect and is added with additional components. Proved by pharmaceutical effect experiments of the applicant andcompared with the prior art, the medicinal composition is simply prepared and has good treatment effect.

Description

technical field [0001] The invention discloses a traditional Chinese medicine composition for treating myasthenia gravis, which belongs to the field of medicine. Background technique [0002] Myasthenia gravis is a kind of combination of acetylcholine receptors on the post-synaptic membrane at the motor nerve and muscle junction with its own antibodies, which reduces the function or number of acetylcholine receptors, resulting in the transfer from the presynaptic membrane of the motor nerve end plate to A disorder in which striated muscles are prone to fatigue due to a reversible blockage of the release of acetylcholine from the postsynaptic membrane. Traditionally, people use anticholinesterase drugs, thymectomy, and radiation therapy to treat myasthenia gravis, but anticholinesterase drugs such as neostigmine and pyridostigmine are temporary and locally effective. The drugs can only temporarily delay the onset of the disease, but long-term use will lead to the destruction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K36/8945A61K36/746A61P21/04A61K35/64A61K35/648
Inventor 郝守祝
Owner 南通集智知识产权服务有限公司
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