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Compound insulin preparation

A technology of insulin and preparations, which is applied in the field of medicine, can solve the problems of decreased insulin effect, drug dependence, and subcutaneous fat atrophy, so as to improve the hypoglycemic effect, eliminate dependence and tolerance, and avoid skin pain Effect

Inactive Publication Date: 2011-07-27
泰州市康特生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008]2. prone to drug dependence
[0009]3. prone to edema
[0010]4. Prone to allergies
[0011]5. Subcutaneous lipoatrophy at the injection site is prone to occur
[0012]6. Prone to drug resistance
Especially for patients who use animal insulin, due to the production of antibodies against insulin in the body, the efficacy of the injected insulin gradually decreases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of Compound Insulin Preparation

[0031] ⑴ Dissolve citric acid or sodium citrate in medical pure water to prepare acidic aqueous solution ① 6ml, control the pH value to 2.5-3.5, and set aside;

[0032] (2) Take 4540 mg of insulin and 40 mg of tetrodotoxin (purity ≥ 99%), dissolve them in acidic aqueous solution ① to obtain 6 ml of preparation solution ②, and set aside;

[0033] (3) Add 5 mg of pyrrolidone (PVP) to solution ②, mix until clear and transparent, and obtain 6 ml of solution ③;

[0034] (4) Take 24ml of polyoxyethylene-40 (hydrogenated pyrene sesame oil), stir for 10 minutes at a constant temperature of 50°C, gradually add 6ml of the solution ③, and continue stirring until there are no bubbles, to obtain 30ml of the solution ④, and set aside;

[0035] ⑸ Take 20g of monoglyceride laurate (GML), melt it completely at 60°C, pour into the solution ④, continue to stir, add fish oil while stirring, so that the total amount reaches 100ml, a...

Embodiment 2

[0038] Example 2 Preparation of Compound Insulin Preparations

[0039] ⑴ Dissolve citric acid or sodium citrate in medical pure water to prepare acidic aqueous solution ① 6ml, control the pH value to 2.5-3.5, and set aside;

[0040] (2) Take 4540 mg of insulin and 40 mg of tetrodotoxin (purity ≥ 99%), dissolve them in acidic aqueous solution ① to obtain 6 ml of preparation solution ②, and set aside;

[0041] (3) Add 5 mg of pyrrolidone (PVP) to solution ②, mix until clear and transparent, and obtain 6 ml of solution ③;

[0042] (4) Take 24ml of polyoxyethylene-40 (hydrogenated pyrene sesame oil), stir for 10 minutes at a constant temperature of 50°C, gradually add 6ml of the solution ③, and continue stirring until there are no bubbles, to obtain 30ml of the solution ④, and set aside;

[0043] ⑸ Take 20g of monoglyceride laurate (GML), melt it completely at 60°C, pour into the solution ④, continue stirring, add perilla seed oil while stirring, so that the total amount reache...

Embodiment 3

[0046] Example 3 Preparation of Compound Insulin Preparations

[0047] ⑴ Dissolve citric acid or sodium citrate in medical pure water to prepare acidic aqueous solution ① 6ml, control the pH value to 2.5-3.5, and set aside;

[0048] (2) Take 4540 mg of insulin and 80 mg of tetrodotoxin (purity ≥ 99%), dissolve them in an acidic aqueous solution ① to obtain 6 ml of preparation solution ②, and set aside;

[0049] (3) Add 5 mg of pyrrolidone (PVP) to solution ②, mix until clear and transparent, and obtain 6 ml of solution ③;

[0050] (4) Take 24ml of polyoxyethylene-40 (hydrogenated pyrene sesame oil), stir for 10 minutes at a constant temperature of 50°C, gradually add 6ml of the solution ③, and continue stirring until there are no bubbles, to obtain 30ml of the solution ④, and set aside;

[0051] ⑸ Take 20g of monoglyceride laurate (GML), melt it completely at 60°C, pour into the solution ④, continue stirring, add perilla seed oil while stirring, so that the total amount reach...

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PUM

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Abstract

The invention provides a compound insulin preparation, which is an oral administration oil preparation prepared by dissolving combined tetrodotoxin and insulin in medical or edible oil, wherein the insulin content is between 0.5 and 10 U / ml, and the tetrodotoxin content is between 0.01 and 10 mu g / ml. In the compound insulin preparation, a trace amount of tetrodotoxin and insulin are combined to form a compound oral administration oil-phase preparation for the defects of the side effect and administration mode of the insulin, so the trouble and flesh bitterness caused by injecting the insulinevery day are prevented, and the side effect of the insulin can be reduced or eliminated.

Description

technical field [0001] The invention relates to a compound insulin preparation and a preparation method thereof, belonging to the technical field of medicine. technical background [0002] Diabetes is a common multiple disease. In the past 20 years, the incidence of diabetes in my country has been increasing significantly. In 2002, the survey data of China Diabetes Research Institute showed that there were 40 million people with diabetes in my country, accounting for 20% of the total number of people with diabetes in the world, and its prevalence rate ranked second in the world. According to the survey data in 2009, there are more than 92 million people with diabetes in my country, and another 150 million people will become patients. This figure shows that at present, the incidence of diabetes in my country has surpassed that of India, becoming the country with the highest incidence of diabetes in the world. Even more worrying is that more and more children have become di...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61P3/10A61K31/529
Inventor 赵继红赵琦汤波澜赵翔
Owner 泰州市康特生物工程有限公司
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