Compound insulin preparation
A technology of insulin and preparations, which is applied in the field of medicine, can solve the problems of decreased insulin effect, drug dependence, and subcutaneous fat atrophy, so as to improve the hypoglycemic effect, eliminate dependence and tolerance, and avoid skin pain Effect
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[0030] Example 1 Preparation of compound insulin preparation
[0031] ⑴ Use citric acid or sodium citrate to dissolve in medical pure water to prepare 6ml acidic aqueous solution ①, control the PH value to 2.5-3.5, and use it for later use;
[0032] ⑵ Take 4540mg of insulin and 40mg of tetrodotoxin (purity ≥99%), and dissolve them in acidic aqueous solution① to obtain 6ml of preparation solution② for use;
[0033] ⑶ Add 5mg of PVP to the solution ②, mix until clear and transparent, and get 6ml of solution ③;
[0034] ⑷ Take 24ml of polyoxyethylene-40 (hydrogenated pyrene oil) and stir for 10 minutes at a constant temperature of 50°C. Gradually drip 6ml of solution ③ and continue stirring until there are no bubbles to obtain 30ml of solution ④ for use;
[0035] ⑸ Take 20g of lauric acid monoglyceride (GML), melt it completely at 60℃, pour the solution ④, continue to stir, while stirring, add fish oil to make the total amount to 100ml, and set aside;
[0036] ⑹ Take 9900ml of fish oil, st...
Example Embodiment
[0038] Example 2 Preparation of compound insulin preparation
[0039] ⑴ Use citric acid or sodium citrate to dissolve in medical pure water to prepare 6ml acidic aqueous solution ①, control the PH value to 2.5-3.5, and use it for later use;
[0040] ⑵ Take 4540mg of insulin and 40mg of tetrodotoxin (purity ≥99%), and dissolve them in acidic aqueous solution① to obtain 6ml of preparation solution② for use;
[0041] ⑶ Add 5mg of PVP to the solution ②, mix until clear and transparent, and get 6ml of solution ③;
[0042] ⑷ Take 24ml of polyoxyethylene-40 (hydrogenated pyrene oil) and stir for 10 minutes at a constant temperature of 50°C. Gradually drip 6ml of solution ③ and continue stirring until there are no bubbles to obtain 30ml of solution ④ for use;
[0043] ⑸ Take 20g of lauric acid monoglyceride (GML), melt it completely at 60℃, pour the solution ④, continue to stir, while stirring, add perilla seed oil to make the total amount to 100ml, for use;
[0044] ⑹ Take 19,900 ml of perilla...
Example Embodiment
[0046] Example 3 Preparation of compound insulin preparation
[0047] ⑴ Use citric acid or sodium citrate to dissolve in medical pure water to prepare 6ml acidic aqueous solution ①, control the PH value to 2.5-3.5, and use it for later use;
[0048] ⑵ Take 4540mg of insulin and 80mg of tetrodotoxin (purity ≥99%), and dissolve it in acidic aqueous solution① to obtain 6ml of preparation solution② for use;
[0049] ⑶ Add 5mg of PVP to the solution ②, mix until clear and transparent, and get 6ml of solution ③;
[0050] ⑷ Take 24ml of polyoxyethylene-40 (hydrogenated pyrene oil) and stir for 10 minutes at a constant temperature of 50°C. Gradually drip 6ml of solution ③ and continue stirring until there are no bubbles to obtain 30ml of solution ④ for use;
[0051] ⑸ Take 20g of lauric acid monoglyceride (GML), melt it completely at 60℃, pour the solution ④, continue to stir, while stirring, add perilla seed oil to make the total amount to 100ml, for use;
[0052] ⑹ Take 19,900 ml of perilla s...
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