Method for manufacturing sustained release microsphere by solvent flow evaporation method

A technology of slow-release microspheres and water solvent, which is applied in the directions of pill delivery, endocrine system diseases, block delivery, etc. It can solve the problems of patients' fear and large size, and achieve the effect of inhibiting the initial excessive release.
CN102137657AInactive Publication Date: 2011-07-27DONG KOOK PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONG KOOK PHARMA CO LTD
Publication Date
2011-07-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method for manufacturing a sustained release microsphere which is able to continuously control the release of a drug. More specifically, the present invention relates to a method for manufacturing a sustained release microsphere through a solvent flow evaporation method using a cosolvent when manufacturing a microsphere in which a drug is sealed in a carrier comprising biodegradable polymers. Thus, early excessive release of a physiologically active substance is suppressed so the physiologically active substance can be continuously and uniformly released in the body.
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Description

technical field

[0001] The invention relates to a preparation method of slow-release microspheres capable of continuously controlling drug release. More specifically, the present invention relates to a method for suppressing initial excessive release of physiologically active substances by solvent exchange evaporation using a co-solvent when preparing microspheres in which a drug is encapsulated in a carrier composed of a biodegradable high molecular polymer. , the preparation method of the slow-release microspheres that enable the sustained and balanced release of physiologically active substances in the body. Background technique

[0002] In the past, common preparation methods for preparing sustained-release injection preparations include coacervation method, melt extrusion method (melt extrusion), spray drying method and solvent evaporation method. Among these methods, the most utilized solvent evaporation method is double emulsification solvent evaporation method (W / O / ...

Claims

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