Preparation method of clindamycin phosphate injection
A technology of clindamycin phosphate and injection, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc., can solve problems such as poor stability, low drug yield, and reduced drug efficacy, etc. Achieve the effect of improving drug stability, improving drug efficacy, and solving dust pollution
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Embodiment 1
[0012] The preparation method of clindamycin phosphate injection, it is prepared by following raw materials, clindamycin phosphate 300g, sodium hydroxide 24.3g, get the sodium hydroxide that meets described parts by weight and be dissolved in In 1500g of water for injection, take the clindamycin phosphate raw material that meets the stated parts by weight and dissolve it in sodium hydroxide solution, stir evenly, add water for injection to dissolve to 2000ml, and then use a 0.65 μm microporous membrane to carry out coarse Filter, and then use a 0.22 μm microporous membrane to carry out fine filtration and sterilization, and fill to obtain clindamycin phosphate injection.
Embodiment 2
[0014] The preparation method of clindamycin phosphate injection, it is prepared by the following raw materials, content is 80% clindamycin phosphate 375g, sodium hydroxide 24.75g, get the content that meets the described parts by weight Dissolve sodium hydroxide in 1700g water for injection, take the clindamycin phosphate raw material that meets the stated parts by weight and dissolve it in the sodium hydroxide solution, stir evenly, add water for injection to dissolve to 2000ml, and then use 0.65 μm micro pore filter membrane for coarse filtration, and then 0.22 μm microporous filter membrane for fine filtration and sterilization, and filling to obtain clindamycin phosphate injection.
Embodiment 3
[0016] The preparation method of clindamycin phosphate injection, it is prepared by the following raw materials, content is 80% clindamycin phosphate 400g, sodium hydroxide 25.5g, get and meet described parts by weight Dissolve sodium hydroxide in 1900g water for injection, take the clindamycin phosphate raw material that meets the stated parts by weight and dissolve it in the sodium hydroxide solution, stir evenly, add water for injection to dissolve to 2000ml, and then use 0.65 μm micro pore filter membrane for coarse filtration, and then 0.22 μm microporous filter membrane for fine filtration and sterilization, and filling to obtain clindamycin phosphate injection.
[0017] The clindamycin phosphate injection that the embodiment of the present invention 1-3 makes and the patent application number are the test data of the quality research of the clindamycin phosphate injection that the 200610134458.1 patent method makes as follows:
[0018] testing sample:
[0019] 1. Sampl...
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