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Method for preparing origanum oil-beta-cyclodextrin inclusion compound feed additive

A cyclodextrin inclusion compound and feed additive technology, which is applied in animal feed, animal feed, additional food elements, etc., can solve the problem of difficulty in improving and guaranteeing the shelf life of bioavailability products, unstable properties of oregano oil, and affecting products. Use effects and other issues to achieve the effects of prolonging drug efficacy and shelf life, improving bioavailability, increasing solubility and dissolution rate

Inactive Publication Date: 2011-09-14
张奎昌
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AI Technical Summary

Problems solved by technology

But because oregano oil is unstable in its properties, volatile, irritating, and bioavailability is low, existing formulation products are difficult to overcome, and the stability of its products is poor, and it is difficult to guarantee its use effect. Mixtures, powders and other dosage forms, the stability, bioavailability and shelf life of the product are difficult to improve and guarantee, which affects the use effect of the product

Method used

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Embodiment Construction

[0013] Get 600 grams of β-cyclodextrin and add an appropriate amount of purified water, heat it to 50° C. to make it all dissolve, and make a β-cyclodextrin solution with a mass concentration of 3%, then take 100 grams of oregano oil with 95% ethanol (according to Its mass ratio) was diluted to 1:3, and the ethanol dilution of oregano oil was added dropwise to the β-cyclodextrin solution under stirring and kept at a constant temperature to 35°C. After the addition was complete, stop heating and keep the speed at 300 rpm Continue to stir for 3 hours, stop stirring and place at room temperature for 12 hours, then refrigerate at 0-5°C for 24 hours, filter with suction, wash with purified water twice from the filter, dry at 40°C, pass through a 80-mesh sieve, and then by P 2 o 5 Vacuum-dried to make the water content 1-3%, and the off-white powdered oregano oil-β-cyclodextrin inclusion complex feed additive product was obtained, the product yield was 93%, and the product inclusio...

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Abstract

The invention relates to a method for preparing an origanum oil-beta-cyclodextrin inclusion compound feed additive. The origanum oil-beta-cyclodextrin inclusion compound feed additive is prepared by carrying out clathration on origanum oil and beta-cyclodextrin according to a mass rate of 1: (5-7) through a coprecipitation method. The origanum oil-beta-cyclodextrin inclusion compound feed additive prepared by using the method has improved water solubility and can be directly added with water for being drunk by livestock and poultry. After an inclusion compound is prepared, drug molecules of the origanum oil are prevented from being in contact with the surrounding environment to a certain extent and are avoided being influenced by light, oxygen and hydrolysis conditions, so that the stability of the drug molecules of the origanum oil is improved, the volatilization of the drug molecules of the origanum oil is reduced, the drug effect and the retention period of the origanum oil-beta-cyclodextrin inclusion compound feed additive are prolonged, the stability of a product is improved, the bioavailability is improved and the using effect is obviously strengthened. The origanum oil-beta-cyclodextrin inclusion compound feed additive can be mixed into a livestock feed for use and can also be used as a drinking agent.

Description

technical field [0001] The invention relates to the field of feed additives, in particular to an oregano oil-β-cyclodextrin inclusion compound feed additive and a preparation method of the additive. Background technique [0002] Oregano oil (Ore gano OiL) is a volatile oil extracted from Origanum vulgare L. of Labiatae, and its chemical composition mainly contains Thymol, parsley Phenol (carvacrol), sesquiterpene, etc. Modern pharmacological studies have shown that the volatile oil in oregano plant has physiological activities such as antibacterial and immune regulation, and is a natural antibacterial drug. [0003] Oregano oil has a unique aroma, which can stimulate the taste receptors of animals. It is a good food attractant. The attachment of pathogenic microorganisms has the function of promoting appetite and the secretion of digestive enzymes, promoting the growth of livestock and poultry, and improving the feed conversion rate. At present, different preparations of i...

Claims

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Application Information

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IPC IPC(8): A23K1/16A23K20/10
Inventor 张奎昌
Owner 张奎昌
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