The invention discloses a preparation method and application of an
infantile anorexia animal model, and belongs to the technical field of medicines. The model can be used for screening, pharmacological research and
efficacy evaluation of medicines for treating child
anorexia. A modeling method of
erythromycin gradient increment
intragastric administration is creatively adopted for the first time, and the child
anorexia animal model is successfully established. Compared with a conventional high-fat and high-
protein-fat feed feeding and central operation modeling mode, the modeling method has the following advantages that the modeling time is shortened, and the modeling
time cost is reduced by two weeks compared with other modeling
modes; compared with expensive high-fat and high-
protein feed, the cost of
erythromycin medicine is 1 / 10 of that of the high-fat and high-
protein feed, and the
time cost is shortened, so that the animal feeding cost is also reduced; the operation technology is simple and convenient; compared with preparation of a high-precision central
anorexia animal model, the experiment operation technology is simple; the conditions for laboratory instruments and equipment are relatively low; the requirements of experimenters are reduced, and the labor cost is reduced.