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Water-soluble porphyrin iron

A porphyrin iron, water-soluble technology, which is applied in the field of preparation of water-soluble porphyrin iron, can solve the problems of poor solubility and difficult absorption of porphyrin iron, and achieve broadened dosage forms, widened the scope of use, significant iron supplementation and anti-oxidation The effect of the function

Inactive Publication Date: 2011-09-14
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, porphyrin iron currently on the market has extremely poor solubility in neutral or low acidity, making it difficult to be absorbed by the body

Method used

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  • Water-soluble porphyrin iron

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 40g of sodium hydroxide and dissolve it in 500mL of ethanol slowly to form a sodium ethoxide solution. Slowly add 10g porphyrin iron and stir evenly. Stirring was continued for 15 h at a temperature of 10° C., and then the stirring was stopped. Afterwards, filter with a sand core funnel, wash with ethanol, and dry to obtain 12 g of aqueous porphyrin iron sodium salt.

Embodiment 2

[0021] Aqueous acetone solution was prepared at a volume ratio of 20:1. Respectively weigh 6 g of crystalline porphyrin iron and 4 g of lysine amino acid, and add them into the acetone solution. Stirring was continued for 20 h at a temperature of 60° C., and then the stirring was stopped. After filtering, the product is washed with acetone and dried to obtain aqueous porphyrin iron.

Embodiment 3

[0023] Aqueous acetone solution was prepared at a volume ratio of 20:1. Then weigh 6 g of crystalline porphyrin iron and 6 g of arginine respectively, and add them into the acetone solution. Stirring was continued for 18 h at a temperature of 50° C., and the stirring was stopped. After filtering, the product is washed with acetone and dried to obtain water-soluble porphyrin iron.

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Abstract

Water-soluble porphyrin iron is prepared by using porphyrin iron, basic amino acids (arginine, lysine), and sodium (potassium) hydroxide as main raw materials; two carboxyl groups on a side chain of a porphyrin ring of porphyrin iron are amidated or salinized by chemical modification to increase the water solubility of porphyrin iron so as to prepare water-soluble porphyrin iron which is soluble in a neutral solution; the water-soluble porphyrin iron is stably added into neutral or weak acidic liquid food in a ferrous-fortifier form, or is used as an iron supplement drug in forms of injections, tablets, capsules and the like in medicine field.

Description

technical field [0001] The invention relates to the preparation of water-soluble porphyrin iron, which mainly uses chemical modification technology to convert water-insoluble porphyrin iron into water-soluble porphyrin iron, thereby expanding the use range and dosage form of porphyrin iron. Background technique [0002] 30%-40% of people in Japan have latent iron deficiency, and 8-13% have obvious iron deficiency anemia, especially children and women. According to a survey by Beijing Medical University, 42% of Chinese 7-year-old boys and 45% of girls. The prevalence rate under 6 years old is 40%. The latest national nutrition survey in my country shows that national iron deficiency has been in the same state as calcium deficiency, and has become an important factor affecting national health. [0003] Iron deficiency is a common problem at home and abroad. On the absorption and nutrition of iron ions, there are many reports that organic iron represented by porphyrin iron (h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22A23L1/30A23L1/305A61K31/409A61P3/02A61P39/06
Inventor 刘安军
Owner TIANJIN UNIV OF SCI & TECH