Antitumor drug with double active components and application thereof

Abstract

The invention discloses an antitumor drug with double active components, and an application thereof. The antitumor drug comprises an independent first active component and an independent second active component. The independent first active component comprises at least two of A, B and C. The A comprises Dipyridamole and pharmaceutically acceptable derivatives of Dipyridamole or pharmaceutically acceptable analogues of Dipyridamole or pharmaceutically acceptable salts of Dipyridamole. The B comprises Ubenimex bestatin and pharmaceutically acceptable derivatives of Ubenimex bestatin or pharmaceutically acceptable analogues of Ubenimex bestatin or pharmaceutically acceptable salts of Ubenimex bestatin. The C comprises Dexamethasone and pharmaceutically acceptable derivatives of Dexamethasone or pharmaceutically acceptable analogues of Dexamethasone. The independent second active component comprises Taxol, ADM, DDP, MMC, 5-FM, Gemcitabine or a tyrosine kinase inhibitor. The antitumor drug provided by the invention can effect on multiple targets and multiple paths, and thus antineoplastic effects of the antitumor drug are clear and obvious.

Description

technical field [0001] The invention relates to a medicine with antitumor effect, in particular to an antitumor medicine comprising dipyridamole, ubenimex and dexamethasone and an antitumor chemotherapeutic medicine. Background technique [0002] The toxicity of currently clinically used antitumor drugs is a prominent problem in tumor chemotherapy. Finding its own low toxicity and acting on specific links or molecular targets in the tumor microenvironment to improve the anti-tumor effect or reduce its toxicity has become a new way to study anti-tumor drugs, and it is also an urgent need for clinical treatment of tumors. [0003] Malignant tumor is a common disease that seriously threatens human health. In today's world, there is an urgent need for anti-tumor drugs. According to the data in 2007, there were 12 million newly diagnosed cancer patients in the world, and 7.6 million people died of cancer. According to the data of the top ten disease mortality and cause of deat...

AI Technical Summary

Problems solved by technology

[0023] Experiments have proved that the effect of using the above drugs alone is not very satisfactory for tumor treatment. Therefore, how to choose appropriate drugs and use them in combination to improve the effect of treating tumors is an important research topic in this field.

Images