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Callicarpa nudiflora Hook. et Arn. extract, preparation method and application thereof

A technique of extracting Auranthus nudiflora, which is applied in the field of extracts of Aurora nudiflora plants, which can solve the problems of time-consuming and labor-intensive, failure to extract fat-soluble medicinal ingredients, and energy consumption, and achieve high extraction rate and active ingredients. The effect of complete content and energy saving

Active Publication Date: 2011-10-05
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing Auranthus nudica extract only contains flavonoids, tannins and some other water-soluble components, and the extraction method usually adopts the traditional heat reflux method, that is, decocting Auranthus nudica in water, filtering, concentrating, Dry the extract, this method is time-consuming, energy-consuming, and most of the fat-soluble medicinal ingredients cannot be extracted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The medicinal material of nude flower purple pearl comes from Hainan, and the content of ursolic acid is 0.21% and the content of verbascoside is 0.32%. Take 100g of crushed herbs and soak them in 800ml of 80% ethanol for 60 minutes. Then, at an ultrasonic frequency of 40kHz, extract for 40min and filter. Add 400ml of 80% ethanol to the filter residue and soak for 60 minutes, repeat the extraction for 20 minutes at an ultrasonic frequency of 40 kHz, filter and combine the two filtrates, recover the ethanol in the filtrate to obtain the alcohol extract extract.

[0022] The ethanol-extracted filter residue was extracted with 1000ml of water as a solvent at an ultrasonic frequency of 40kHz for 40min, and then filtered, and the water extract was concentrated under reduced pressure to obtain a water extract extract.

[0023] The two extracts were combined, mixed, 0.85Mpa, 60 ℃ vacuum concentration to a thick paste. The above thick paste is vacuum-dried at 0.85MPa and 60°C...

Embodiment 2

[0026] The medicinal material of nude flower purple pearl comes from Hainan, and the content of ursolic acid is 0.21% and the content of verbascoside is 0.32%. Take 100g of crushed herbs and soak them in 700ml of 70% ethanol for 90 minutes. Then, at an ultrasonic frequency of 40kHz, extract for 30min and filter. Add 300ml of 70% ethanol to the filter residue and soak for 90 minutes, repeat the extraction for 15 minutes at an ultrasonic frequency of 40 kHz, filter and combine the two filtrates, recover the ethanol in the filtrate to obtain the alcohol extract extract.

[0027] The ethanol-extracted filter residue was extracted with 1200ml of water as a solvent at an ultrasonic frequency of 40kHz for 50min, and then filtered, and the water extract was concentrated under reduced pressure to obtain a water extract extract.

[0028] The two extracts were combined, mixed, 0.85Mpa, 60 ℃ vacuum concentration to a thick paste. The above thick paste is vacuum-dried at 0.85MPa and 60°C...

Embodiment 3

[0030] The medicinal material of nude flower purple pearl comes from Hainan, and the content of ursolic acid is 0.21% and the content of verbascoside is 0.32%. Take 100g of crushed herbs and soak them in 700ml of 90% ethanol for 70 minutes. Then, at an ultrasonic frequency of 40kHz, extract for 30min and filter. Add 400ml of 90% ethanol to the filter residue and soak for 70 minutes, repeat the extraction for 25 minutes at an ultrasonic frequency of 40 kHz, filter and combine the two filtrates, recover the ethanol in the filtrate to obtain the alcohol extract extract.

[0031] The ethanol-extracted filter residue was then extracted with 800ml of water as a solvent at an ultrasonic frequency of 40kHz for 30min, and then filtered, and the water extract was concentrated under reduced pressure to obtain a water extract extract.

[0032] The two extracts were combined, mixed, 0.85Mpa, 60 ℃ vacuum concentration to a thick paste. The above thick paste is vacuum-dried at 0.85MPa and ...

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Abstract

Relating to the field of traditional Chinese medicine preparation, the invention provides a Callicarpa nudiflora Hook. et Arn. extract, and its preparation method and application. Containing flavonoid and water-soluble ingredients, the Callicarpa nudiflora Hook. et Arn. extract is characterized by additionally containing diterpene and triterpene fat-soluble ingredients. The Callicarpa nudiflora Hook. et Arn. extract of the invention is extracted by supersonic waves for preparing bacteriostatic, antiphlogistic, hemostatic and astringent medicaments. The beneficial effect of the extract provided in the invention is that: not only containing flavonoid, tannin and other water-soluble ingredients, but also containing diterpene and triterpene fat-soluble ingredients, the extract of the invention has more complete active ingredients and a comparatively increased content, thus being beneficial to the application of various preparations. Requiring no heating, the preparation method of the invention is energy saving and of high extraction rate.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to an extract of Auranthus nudiflora, a preparation method of the extract and uses of the extract. Background technique [0002] Zizhu nudiflora is the dry leaf of Zizhu nudiflora of Verbenaceae plant. It has the functions of hemostasis, antibacterial, astringent, detoxification, analgesia and promotion of healing when used in medicine. The main components of Auranthus nudica are flavonoids, diterpenoids and triterpenoids, condensed tannins, phenols, polysaccharides, hydroxyl compounds, and water-soluble components such as magnesium, calcium, and iron salts. Among them, flavonoids include verbascoside, Luteolin and luteolin, etc., the total flavonoid content is as high as about 5%, diterpenoids and triterpenoids include ursolic acid and oleanolic acid, etc. The relevant literature reports and experimental results show that the extract of Asteraceae Some triterpe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P31/04A61P29/00A61P7/04A61P17/02
Inventor 肖军平吴永忠余宝平李旭刘立鼎
Owner JIANGXI POZIN PHARMA
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