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Method for preparing aspirin and dipyridamole multilayer tablets

A technology for aspirin and dipyridamole, which is applied in the field of preparation of pharmaceutical compositions, can solve the problems of high price of a three-layer tablet machine, inability to realize the preparation of three-layer tablets, and the like

Active Publication Date: 2011-10-12
SHANDONG XINHUA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process needs to be completed on a three-layer tablet press, but the three-layer tablet press is expensive and requires a lot of money to purchase equipment, while ordinary tablet presses can only press single-layer tablets, and cannot realize the preparation of the three-layer tablet

Method used

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  • Method for preparing aspirin and dipyridamole multilayer tablets
  • Method for preparing aspirin and dipyridamole multilayer tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] The preparation method of aspirin and dipyridamole composition is as follows:

[0022] A: Preparation of dipyridamole sustained-release layer

[0023] Dipyridamole 200g

[0024] HPMC K4M 19g

[0025] Fumaric acid 200g

[0026] Isopropanol 70g

[0027] Magnesium Stearate 9g

[0028]

[0029] A total of 1000 pieces were made

[0030] Weigh dipyridamole and HPMC according to the prescription amount K4M and fumaric acid, placed in a fast stirring granulator (KJZ-10 type, Shanghai Xinyi Pharmaceutical Technology Equipment Co., Ltd.) and mixed for 15min, with isopropanol as a wetting liquid, added to the fast stirring granulator and stirred rapidly Cut for 2 minutes, dry the prepared wet granules in a drying oven at 60±5°C for 5 hours to make the water content <1% (wt), pass through a 16-mesh sieve for granulation, add magnesium stearate, mix well, and place it into a tablet On the machine (C&C800 type, Beijing Chuangbo Jiawei Technology ...

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Abstract

The invention provides a method for preparing aspirin and dipyridamole multilayer tablets, which is characterized by comprising: preparing dipyridamole sustained-release tablet cores by tabletting; and coating a stomach soluble insulation layer, an aspirin quick-release layer and a stomach soluble protective layer in turn. The method has the advantage that aspirin common release and dipyridamole sustained-release compound preparations are prepared by using conventional pharmaceutical equipment.

Description

technical field [0001] The invention relates to the preparation of a pharmaceutical composition, in particular to a method for preparing multilayer tablets of dipyridamole sustained release and aspirin common release. Background technique [0002] Compound solid preparations of aspirin and dipyridamole have been used clinically in recent years. It is recommended by the World Health Organization as the drug of choice for antithrombotics. The American Association of Antiplatelet Experimenters, the famous PARISI experiment confirmed that it is the best drug for the prevention and treatment of myocardial infarction. German company Boehinger Ingelheim first developed compound aspirin dipyridamole sustained-release capsules, trade name: In 1999, it was approved for marketing by the FDA of the United States, and it has been sold and used in many countries such as the United Kingdom and France. It can reduce the risk of stroke in patients who have had a transient stroke or ische...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K31/519A61K9/28A61P7/02
Inventor 汪洋刘怀林潘西海
Owner SHANDONG XINHUA PHARMA CO LTD
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