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Soft capsule for treating cardiovascular diseases and preparation method thereof

A soft capsule, soft capsule technology, applied in the field of Chinese patent medicine and its preparation, can solve the problems of easy water absorption and soft capsule shell, low bioavailability, poor stability, etc., to improve bioavailability, avoid Good hygroscopicity and compliance of the drug

Active Publication Date: 2013-12-04
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Yinshen Tongluo capsules have poor stability, are easy to absorb water and become soft or dry and crack, causing the capsule shell to rupture, slow absorption, and low bioavailability

Method used

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  • Soft capsule for treating cardiovascular diseases and preparation method thereof
  • Soft capsule for treating cardiovascular diseases and preparation method thereof
  • Soft capsule for treating cardiovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 A kind of preparation method of Yinshen Tongluo soft capsule is carried out as follows:

[0039] 1. Preparation of Ginkgo biloba extract:

[0040] (1) crude product preparation

[0041]Crush 1000g of ginkgo leaves into 0.3-0.5cm fragments, add 2 times the weight of ginkgo leaves with 70% ethanol to infiltrate and extract at 60°C for 2 hours each time, extract twice in total, combine the extracts, and recover Described ethanol reaches relative density 1.03~1.09 (50 ℃), then adds the ethanol of the volume percent concentration that is equal to the weight of ginkgo leaf and is 70% and the water that accounts for 4 times weight of ginkgo leaf, 1~4 ℃ refrigerates and places 8h, filters , DM130 macroporous adsorption resin column on the filtrate, respectively with the water of 3~4 times of column volume, the volume percentage concentration of 3 times of column volume is the ethanol of 15%, the volume percentage concentration of 1 times of column volume is the et...

Embodiment 2～6

[0073] Embodiments 2 to 6: According to the following raw and auxiliary materials and dosage ratios, the rest are the same as in Embodiment 1, and the following are all in weight percentage.

[0074]

[0075]

[0076]

[0077] The present invention has carried out research and investigation to its stability, and concrete investigation method and result are as follows:

[0078] Stability test

[0079] a. Accelerated test

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PUM

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Abstract

The invention relates to a soft capsule for treating cardiovascular diseases, named a Yinshen Tongluo soft capsule. The soft capsule is prepared from an effective amount of traditional Chinese medicine extracts of ginkgo leaf, ginseng, ligusticum wallichii and Schisandra chinensis and pharmaceutical excipients, wherein the pharmaceutical excipients include a diluent, a suspending aid and a capsule shell material; the capsule shell material is one or more then one of gelatin, poly(vinyl alcohol), hydroxypropyl starch, hydroxyethyl starch, starch succinate and a plasticizer; the diluent is composed of a vegetable oil and poly(ethylene glycol) 400; and the suspending aid is beeswax. The Yinshen Tongluo soft capsule provided by the invention has the advantages of fast drug release, high blood concentration, effectively improved bioavailability, good stability, beautiful appearance and good patient adaptability. The preparation method of the soft capsule for treating cardiovascular diseases provided by the invention can fully extract active ingredients from the traditional Chinese medicines, improve the contents of the active ingredients in the product, and effectively increase drug adaptability and efficacy; and simultaneously the preparation method of the soft capsule preparation has high product yield (up to 96%).

Description

technical field [0001] The invention relates to a Chinese patent medicine and a preparation method thereof, in particular to a capsule for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health, and coronary heart disease is one of the chief culprits. The current situation of coronary heart disease and several risk factors According to the latest statistics, 17 million people died of cardiovascular disease in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world, and this number is expected to increase by 2020. to 25 million, 80 percent of which are in developing countries. [0003] The cause of coronary heart disease is still unclear, but the risk factors of coronary heart disease are very clear. Insufficient blood supply to the myocardium, or even complete blockage, and obvious ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/34A61K47/42A61K47/44A61K36/57A61P9/10
Inventor 田建刘行鹏向洪昝琼
Owner TIANSHENG PHARMA GROUP